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Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging
Ultrasound-sensitive (sonosensitive) liposomes for tumor targeting have been studied in order to increase the antitumor efficacy of drugs and decrease the associated severe side effects. Liposomal contrast agents having Gd(III) are known as a nano-contrast agent system for the efficient and selectiv...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522036/ https://www.ncbi.nlm.nih.gov/pubmed/22901317 http://dx.doi.org/10.1186/1556-276X-7-462 |
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author | Jung, Suk Hyun Na, Kyunga Lee, Seul A Cho, Sun Hang Seong, Hasoo Shin, Byung Cheol |
author_facet | Jung, Suk Hyun Na, Kyunga Lee, Seul A Cho, Sun Hang Seong, Hasoo Shin, Byung Cheol |
author_sort | Jung, Suk Hyun |
collection | PubMed |
description | Ultrasound-sensitive (sonosensitive) liposomes for tumor targeting have been studied in order to increase the antitumor efficacy of drugs and decrease the associated severe side effects. Liposomal contrast agents having Gd(III) are known as a nano-contrast agent system for the efficient and selective delivery of contrast agents into pathological sites. The objective of this study was to prepare Gd(III)-DOTA-modified sonosensitive liposomes (GdSL), which could deliver a model drug, doxorubicin (DOX), to a specific site and, at the same time, be capable of magnetic resonance (MR) imaging. The GdSL was prepared using synthesized Gd(III)-DOTA-1,2-distearoyl-sn-glycero-3-phosphoethanolamine lipid. Sonosensitivity of GdSL to 20-kHz ultrasound induced 33% to 40% of DOX release. The relaxivities (r(1)) of GdSL were 6.6 to 7.8 mM(−1) s(−1), which were higher than that of MR-bester®. Intracellular uptake properties of GdSL were evaluated according to the intensity of ultrasound. Intracellular uptake of DOX for ultrasound-triggered GdSL was higher than that for non-ultrasound-triggered GdSL. The results of our study suggest that the paramagnetic and sonosensitive liposomes, GdSL, may provide a versatile platform for molecular imaging and targeted drug delivery. |
format | Online Article Text |
id | pubmed-3522036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-35220362012-12-18 Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging Jung, Suk Hyun Na, Kyunga Lee, Seul A Cho, Sun Hang Seong, Hasoo Shin, Byung Cheol Nanoscale Res Lett Nano Express Ultrasound-sensitive (sonosensitive) liposomes for tumor targeting have been studied in order to increase the antitumor efficacy of drugs and decrease the associated severe side effects. Liposomal contrast agents having Gd(III) are known as a nano-contrast agent system for the efficient and selective delivery of contrast agents into pathological sites. The objective of this study was to prepare Gd(III)-DOTA-modified sonosensitive liposomes (GdSL), which could deliver a model drug, doxorubicin (DOX), to a specific site and, at the same time, be capable of magnetic resonance (MR) imaging. The GdSL was prepared using synthesized Gd(III)-DOTA-1,2-distearoyl-sn-glycero-3-phosphoethanolamine lipid. Sonosensitivity of GdSL to 20-kHz ultrasound induced 33% to 40% of DOX release. The relaxivities (r(1)) of GdSL were 6.6 to 7.8 mM(−1) s(−1), which were higher than that of MR-bester®. Intracellular uptake properties of GdSL were evaluated according to the intensity of ultrasound. Intracellular uptake of DOX for ultrasound-triggered GdSL was higher than that for non-ultrasound-triggered GdSL. The results of our study suggest that the paramagnetic and sonosensitive liposomes, GdSL, may provide a versatile platform for molecular imaging and targeted drug delivery. Springer 2012-08-17 /pmc/articles/PMC3522036/ /pubmed/22901317 http://dx.doi.org/10.1186/1556-276X-7-462 Text en Copyright ©2012 Jung et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Nano Express Jung, Suk Hyun Na, Kyunga Lee, Seul A Cho, Sun Hang Seong, Hasoo Shin, Byung Cheol Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging |
title | Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging |
title_full | Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging |
title_fullStr | Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging |
title_full_unstemmed | Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging |
title_short | Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging |
title_sort | gd(iii)-dota-modified sonosensitive liposomes for ultrasound-triggered release and mr imaging |
topic | Nano Express |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522036/ https://www.ncbi.nlm.nih.gov/pubmed/22901317 http://dx.doi.org/10.1186/1556-276X-7-462 |
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