Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15

The opposing regulators of ubiquitylation status, E3 ligases and deubiquitylases, are often found to be associated in complexes. Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related...

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Detalles Bibliográficos
Autores principales: Hayes, Sebastian D., Liu, Han, MacDonald, Ewan, Sanderson, Christopher M., Coulson, Judy M., Clague, Michael J., Urbé, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522295/
https://www.ncbi.nlm.nih.gov/pubmed/23105109
http://dx.doi.org/10.1074/jbc.M112.386938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522295/
https://www.ncbi.nlm.nih.gov/pubmed/23105109
http://dx.doi.org/10.1074/jbc.M112.386938

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