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The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

In vitro studies have shown that neuronal cell cultures secrete exosomes containing amyloid-β precursor protein (APP) and the APP-processing products, C-terminal fragments (CTFs) and amyloid-β (Aβ). We investigated the secretion of full-length APP (flAPP) and APP CTFs via the exosome secretory pathw...

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Detalles Bibliográficos
Autores principales:	Perez-Gonzalez, Rocio, Gauthier, Sebastien A., Kumar, Asok, Levy, Efrat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522305/ https://www.ncbi.nlm.nih.gov/pubmed/23129776 http://dx.doi.org/10.1074/jbc.M112.404467

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