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Prevalence of Perinatal Central Nervous System Anomalies in East Azarbaijan-Iran

BACKGROUND/OBJECTIVE: Central nervous system (CNS) anomalies are the most serious congenital abnormalities. Ultrasound examination is an effective and noninvasive modality for prenatal diagnosis of these anomalies. The purpose of the current study was to determine the frequency of CNS and associated...

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Autores principales: Ghavami, M., Abedinzadeh, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522319/
https://www.ncbi.nlm.nih.gov/pubmed/23329921
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author Ghavami, M.
Abedinzadeh, R.
author_facet Ghavami, M.
Abedinzadeh, R.
author_sort Ghavami, M.
collection PubMed
description BACKGROUND/OBJECTIVE: Central nervous system (CNS) anomalies are the most serious congenital abnormalities. Ultrasound examination is an effective and noninvasive modality for prenatal diagnosis of these anomalies. The purpose of the current study was to determine the frequency of CNS and associated abnormalities. PATIENTS AND METHODS: A total of 22500 pregnant women who were referred by obstetricians/gynecologists for routine work up of pregnancy were scanned over a period of 3 years by two expert sonologists in a referral center using high resolution ultrasound unit. RESULTS: After transabdominal sonographic examination of 22500 pregnant women, 112 (0.5%) fetuses were detected with CNS anomalies, some of whom had more than one anomaly. Forty-one (37%) Chiari malformations, 26 (23%) monro and aqueductal stenosis cases, 18 (16%) anencephaly cases, nine (8%) encephaloceles, seven (6%) microcephalies, five (4%) Dandywalker syndromes, two (2%) arachnoid cysts, two (2%) agenesis of corpus callosum cases, one (1%) holoprosencephaly and one (1%) schizencephaly were reported in our study. CONCLUSION: According to our results, Chiari malformation and hydrocephalus were the most prevalent anomalies of CNS congenital abnormalities in East Azarbaijan, Iran. An accurate diagnosis depends upon fetal age, amniotic fluid volume, fetal position, operator experience and careful evaluation of the associated malformations, which are often present.
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spelling pubmed-35223192013-01-17 Prevalence of Perinatal Central Nervous System Anomalies in East Azarbaijan-Iran Ghavami, M. Abedinzadeh, R. Iran J Radiol Urogenital Imaging BACKGROUND/OBJECTIVE: Central nervous system (CNS) anomalies are the most serious congenital abnormalities. Ultrasound examination is an effective and noninvasive modality for prenatal diagnosis of these anomalies. The purpose of the current study was to determine the frequency of CNS and associated abnormalities. PATIENTS AND METHODS: A total of 22500 pregnant women who were referred by obstetricians/gynecologists for routine work up of pregnancy were scanned over a period of 3 years by two expert sonologists in a referral center using high resolution ultrasound unit. RESULTS: After transabdominal sonographic examination of 22500 pregnant women, 112 (0.5%) fetuses were detected with CNS anomalies, some of whom had more than one anomaly. Forty-one (37%) Chiari malformations, 26 (23%) monro and aqueductal stenosis cases, 18 (16%) anencephaly cases, nine (8%) encephaloceles, seven (6%) microcephalies, five (4%) Dandywalker syndromes, two (2%) arachnoid cysts, two (2%) agenesis of corpus callosum cases, one (1%) holoprosencephaly and one (1%) schizencephaly were reported in our study. CONCLUSION: According to our results, Chiari malformation and hydrocephalus were the most prevalent anomalies of CNS congenital abnormalities in East Azarbaijan, Iran. An accurate diagnosis depends upon fetal age, amniotic fluid volume, fetal position, operator experience and careful evaluation of the associated malformations, which are often present. Kowsar 2011-09 2011-09-25 /pmc/articles/PMC3522319/ /pubmed/23329921 Text en Copyright © 2011, Tehran University of Medical Sciences and Iranian Society of Radiology http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Urogenital Imaging
Ghavami, M.
Abedinzadeh, R.
Prevalence of Perinatal Central Nervous System Anomalies in East Azarbaijan-Iran
title Prevalence of Perinatal Central Nervous System Anomalies in East Azarbaijan-Iran
title_full Prevalence of Perinatal Central Nervous System Anomalies in East Azarbaijan-Iran
title_fullStr Prevalence of Perinatal Central Nervous System Anomalies in East Azarbaijan-Iran
title_full_unstemmed Prevalence of Perinatal Central Nervous System Anomalies in East Azarbaijan-Iran
title_short Prevalence of Perinatal Central Nervous System Anomalies in East Azarbaijan-Iran
title_sort prevalence of perinatal central nervous system anomalies in east azarbaijan-iran
topic Urogenital Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522319/
https://www.ncbi.nlm.nih.gov/pubmed/23329921
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