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No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease
BACKGROUND/AIMS: PiggyBac transposable element derived 1 (PGBD1) encodes a molecule involved in epigenetic mechanisms that have been implicated in Alzheimer's disease (AD), and recent genome-wide association studies and meta-analyses have indicated that a single nucleotide polymorphism (SNP), r...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522449/ https://www.ncbi.nlm.nih.gov/pubmed/23277782 http://dx.doi.org/10.1159/000345085 |
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author | Ohnuma, Tohru Nakamura, Tohru Takebayashi, Yuto Hanzawa, Ryo Kitazawa, Maiko Higashiyama, Ryoko Takeda, Mayu Thompson, Katrin Komatsu, Miwa Shimazaki, Hiromi Shibata, Nobuto Arai, Heii |
author_facet | Ohnuma, Tohru Nakamura, Tohru Takebayashi, Yuto Hanzawa, Ryo Kitazawa, Maiko Higashiyama, Ryoko Takeda, Mayu Thompson, Katrin Komatsu, Miwa Shimazaki, Hiromi Shibata, Nobuto Arai, Heii |
author_sort | Ohnuma, Tohru |
collection | PubMed |
description | BACKGROUND/AIMS: PiggyBac transposable element derived 1 (PGBD1) encodes a molecule involved in epigenetic mechanisms that have been implicated in Alzheimer's disease (AD), and recent genome-wide association studies and meta-analyses have indicated that a single nucleotide polymorphism (SNP), rs3800324, in PGBD1 could be associated with AD and the age of onset. However, no Japanese patients were examined in these studies. The aim of the present study was to replicate the previous finding in Japanese AD cases. METHODS: We performed a case-control study (211 cases and 156 controls) to investigate the association between PGBD1 and Japanese AD using 4 tag SNPs including rs3800324. RESULTS: Single SNP and haplotype analysis showed no association between AD and age of onset, whereas genotypic and allelic frequencies of the ∊4 of apolipoprotein E (APOE) showed an association with AD as expected. CONCLUSION: In Japanese AD, we observed no influence of PGBD1, as either a risk factor or a modifier, even though APOE was associated with AD in this population. |
format | Online Article Text |
id | pubmed-3522449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-35224492012-12-31 No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease Ohnuma, Tohru Nakamura, Tohru Takebayashi, Yuto Hanzawa, Ryo Kitazawa, Maiko Higashiyama, Ryoko Takeda, Mayu Thompson, Katrin Komatsu, Miwa Shimazaki, Hiromi Shibata, Nobuto Arai, Heii Dement Geriatr Cogn Dis Extra Original Research Article BACKGROUND/AIMS: PiggyBac transposable element derived 1 (PGBD1) encodes a molecule involved in epigenetic mechanisms that have been implicated in Alzheimer's disease (AD), and recent genome-wide association studies and meta-analyses have indicated that a single nucleotide polymorphism (SNP), rs3800324, in PGBD1 could be associated with AD and the age of onset. However, no Japanese patients were examined in these studies. The aim of the present study was to replicate the previous finding in Japanese AD cases. METHODS: We performed a case-control study (211 cases and 156 controls) to investigate the association between PGBD1 and Japanese AD using 4 tag SNPs including rs3800324. RESULTS: Single SNP and haplotype analysis showed no association between AD and age of onset, whereas genotypic and allelic frequencies of the ∊4 of apolipoprotein E (APOE) showed an association with AD as expected. CONCLUSION: In Japanese AD, we observed no influence of PGBD1, as either a risk factor or a modifier, even though APOE was associated with AD in this population. S. Karger AG 2012-11-10 /pmc/articles/PMC3522449/ /pubmed/23277782 http://dx.doi.org/10.1159/000345085 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Original Research Article Ohnuma, Tohru Nakamura, Tohru Takebayashi, Yuto Hanzawa, Ryo Kitazawa, Maiko Higashiyama, Ryoko Takeda, Mayu Thompson, Katrin Komatsu, Miwa Shimazaki, Hiromi Shibata, Nobuto Arai, Heii No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease |
title | No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease |
title_full | No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease |
title_fullStr | No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease |
title_full_unstemmed | No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease |
title_short | No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease |
title_sort | no associations found between pgbd1 and the age of onset in japanese patients diagnosed with sporadic alzheimer's disease |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522449/ https://www.ncbi.nlm.nih.gov/pubmed/23277782 http://dx.doi.org/10.1159/000345085 |
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