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Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity

The aim of the study was to evaluate the effect of resveratrol in doxorubicin-induced cardiac and hepatic toxicity. Doxorubicin was administered once a week throughout the period of 7 weeks with 1.0 or 2.0 mg/kg body weight or concomitantly with resveratrol (20 mg/kg of feed). Heart and liver toxici...

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Autores principales: Dudka, Jaroslaw, Gieroba, Renata, Korga, Agnieszka, Burdan, Franciszek, Matysiak, Wlodzimierz, Jodlowska-Jedrych, Barbara, Mandziuk, Slawomir, Korobowicz, Elzbieta, Murias, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522488/
https://www.ncbi.nlm.nih.gov/pubmed/23258992
http://dx.doi.org/10.1155/2012/606183
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author Dudka, Jaroslaw
Gieroba, Renata
Korga, Agnieszka
Burdan, Franciszek
Matysiak, Wlodzimierz
Jodlowska-Jedrych, Barbara
Mandziuk, Slawomir
Korobowicz, Elzbieta
Murias, Marek
author_facet Dudka, Jaroslaw
Gieroba, Renata
Korga, Agnieszka
Burdan, Franciszek
Matysiak, Wlodzimierz
Jodlowska-Jedrych, Barbara
Mandziuk, Slawomir
Korobowicz, Elzbieta
Murias, Marek
author_sort Dudka, Jaroslaw
collection PubMed
description The aim of the study was to evaluate the effect of resveratrol in doxorubicin-induced cardiac and hepatic toxicity. Doxorubicin was administered once a week throughout the period of 7 weeks with 1.0 or 2.0 mg/kg body weight or concomitantly with resveratrol (20 mg/kg of feed). Heart and liver toxicity was histologically and biochemically evaluated. Resveratrol protected from the heart lipid peroxidation caused by 1 mg doxorubicin and it sharply diminished superoxide dismutase activity. An insignificant effect of resveratrol on the lipid peroxidation level and the superoxide dismutase activity was observed in the hearts of rats administered a higher dose of doxorubicin. However, resveratrol attenuate necrosis and other cardiac histopathological changes were induced by a high dose of doxorubicin. Interestingly, it slightly intensified adverse cardiac histological changes in rats receiving a lower dose of doxorubicin. Resveratrol did not have any protective effect on the hepatic oxidative stress, while exerting a mild beneficial effect on the morphological changes caused by doxorubicin. All in all, this study has shown different effects of resveratrol on dose-related doxorubicin-induced heart and liver toxicity. Resveratrol may modulate the hepatic and cardiac effect of doxorubicin, depending on the drug dose.
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spelling pubmed-35224882012-12-20 Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity Dudka, Jaroslaw Gieroba, Renata Korga, Agnieszka Burdan, Franciszek Matysiak, Wlodzimierz Jodlowska-Jedrych, Barbara Mandziuk, Slawomir Korobowicz, Elzbieta Murias, Marek Evid Based Complement Alternat Med Research Article The aim of the study was to evaluate the effect of resveratrol in doxorubicin-induced cardiac and hepatic toxicity. Doxorubicin was administered once a week throughout the period of 7 weeks with 1.0 or 2.0 mg/kg body weight or concomitantly with resveratrol (20 mg/kg of feed). Heart and liver toxicity was histologically and biochemically evaluated. Resveratrol protected from the heart lipid peroxidation caused by 1 mg doxorubicin and it sharply diminished superoxide dismutase activity. An insignificant effect of resveratrol on the lipid peroxidation level and the superoxide dismutase activity was observed in the hearts of rats administered a higher dose of doxorubicin. However, resveratrol attenuate necrosis and other cardiac histopathological changes were induced by a high dose of doxorubicin. Interestingly, it slightly intensified adverse cardiac histological changes in rats receiving a lower dose of doxorubicin. Resveratrol did not have any protective effect on the hepatic oxidative stress, while exerting a mild beneficial effect on the morphological changes caused by doxorubicin. All in all, this study has shown different effects of resveratrol on dose-related doxorubicin-induced heart and liver toxicity. Resveratrol may modulate the hepatic and cardiac effect of doxorubicin, depending on the drug dose. Hindawi Publishing Corporation 2012 2012-11-26 /pmc/articles/PMC3522488/ /pubmed/23258992 http://dx.doi.org/10.1155/2012/606183 Text en Copyright © 2012 Jaroslaw Dudka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dudka, Jaroslaw
Gieroba, Renata
Korga, Agnieszka
Burdan, Franciszek
Matysiak, Wlodzimierz
Jodlowska-Jedrych, Barbara
Mandziuk, Slawomir
Korobowicz, Elzbieta
Murias, Marek
Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity
title Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity
title_full Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity
title_fullStr Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity
title_full_unstemmed Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity
title_short Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity
title_sort different effects of resveratrol on dose-related doxorubicin-induced heart and liver toxicity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522488/
https://www.ncbi.nlm.nih.gov/pubmed/23258992
http://dx.doi.org/10.1155/2012/606183
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