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Premature Translational Termination Products Are Rapidly Degraded Substrates for MHC Class I Presentation

Nearly thirty percent of all newly synthesized polypeptides are targeted for rapid proteasome-mediated degradation. These rapidly degraded polypeptides (RDPs) are a source of antigenic substrates for the MHC class I presentation pathway, allowing for immunosurveillance of newly synthesized proteins...

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Detalles Bibliográficos
Autores principales:	Lacsina, Joshua R., Marks, Odessa A., Liu, Xiongfei, Reid, David W., Jagannathan, Sujatha, Nicchitta, Christopher V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522582/ https://www.ncbi.nlm.nih.gov/pubmed/23251665 http://dx.doi.org/10.1371/journal.pone.0051968

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