Cargando…

Association of the IL1RN Gene VNTR Polymorphism with Human Male Infertility

Interleukin-1 (IL-1) is a regulatory cytokine that plays an important role in the maintenance of the immune environment of the testis, regulation of junction dynamics and cell differentiation during spermatogenesis. Members of the IL-1 family are pleiotropic cytokines that are involved in inflammati...

Descripción completa

Detalles Bibliográficos
Autores principales: Jaiswal, Deepika, Trivedi, Sameer, Singh, Rajendra, Dada, Rima, Singh, Kiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522614/
https://www.ncbi.nlm.nih.gov/pubmed/23251650
http://dx.doi.org/10.1371/journal.pone.0051899
_version_ 1782253099035918336
author Jaiswal, Deepika
Trivedi, Sameer
Singh, Rajendra
Dada, Rima
Singh, Kiran
author_facet Jaiswal, Deepika
Trivedi, Sameer
Singh, Rajendra
Dada, Rima
Singh, Kiran
author_sort Jaiswal, Deepika
collection PubMed
description Interleukin-1 (IL-1) is a regulatory cytokine that plays an important role in the maintenance of the immune environment of the testis, regulation of junction dynamics and cell differentiation during spermatogenesis. Members of the IL-1 family are pleiotropic cytokines that are involved in inflammation, immunoregulation and other homeostatic functions in the body. IL-1α, IL-1β, and the IL-1 receptor antagonistic molecule (IL-1 Ra) are expressed in the testis under normal homeostasis and they further increase upon infection/inflammation. In the present study we have examined the association of Variable Number Tandem Repeats (VNTR) polymorphism of the Interleukin-1 receptor antagonist gene (IL1RN) with human male infertility. The case-control study comprised of two groups: 331 idiopathic infertile patients and 358 fertile healthy men. The study indicates risk of IL1RN2 variant with male infertility (OR: 1.43, CI: 1.1546 to 1.7804, P = 0.001). To our best knowledge, this is the first report that links IL1RN VNTR polymorphism with human male infertility.
format Online
Article
Text
id pubmed-3522614
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-35226142012-12-18 Association of the IL1RN Gene VNTR Polymorphism with Human Male Infertility Jaiswal, Deepika Trivedi, Sameer Singh, Rajendra Dada, Rima Singh, Kiran PLoS One Research Article Interleukin-1 (IL-1) is a regulatory cytokine that plays an important role in the maintenance of the immune environment of the testis, regulation of junction dynamics and cell differentiation during spermatogenesis. Members of the IL-1 family are pleiotropic cytokines that are involved in inflammation, immunoregulation and other homeostatic functions in the body. IL-1α, IL-1β, and the IL-1 receptor antagonistic molecule (IL-1 Ra) are expressed in the testis under normal homeostasis and they further increase upon infection/inflammation. In the present study we have examined the association of Variable Number Tandem Repeats (VNTR) polymorphism of the Interleukin-1 receptor antagonist gene (IL1RN) with human male infertility. The case-control study comprised of two groups: 331 idiopathic infertile patients and 358 fertile healthy men. The study indicates risk of IL1RN2 variant with male infertility (OR: 1.43, CI: 1.1546 to 1.7804, P = 0.001). To our best knowledge, this is the first report that links IL1RN VNTR polymorphism with human male infertility. Public Library of Science 2012-12-14 /pmc/articles/PMC3522614/ /pubmed/23251650 http://dx.doi.org/10.1371/journal.pone.0051899 Text en © 2012 Jaiswal et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jaiswal, Deepika
Trivedi, Sameer
Singh, Rajendra
Dada, Rima
Singh, Kiran
Association of the IL1RN Gene VNTR Polymorphism with Human Male Infertility
title Association of the IL1RN Gene VNTR Polymorphism with Human Male Infertility
title_full Association of the IL1RN Gene VNTR Polymorphism with Human Male Infertility
title_fullStr Association of the IL1RN Gene VNTR Polymorphism with Human Male Infertility
title_full_unstemmed Association of the IL1RN Gene VNTR Polymorphism with Human Male Infertility
title_short Association of the IL1RN Gene VNTR Polymorphism with Human Male Infertility
title_sort association of the il1rn gene vntr polymorphism with human male infertility
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522614/
https://www.ncbi.nlm.nih.gov/pubmed/23251650
http://dx.doi.org/10.1371/journal.pone.0051899
work_keys_str_mv AT jaiswaldeepika associationoftheil1rngenevntrpolymorphismwithhumanmaleinfertility
AT trivedisameer associationoftheil1rngenevntrpolymorphismwithhumanmaleinfertility
AT singhrajendra associationoftheil1rngenevntrpolymorphismwithhumanmaleinfertility
AT dadarima associationoftheil1rngenevntrpolymorphismwithhumanmaleinfertility
AT singhkiran associationoftheil1rngenevntrpolymorphismwithhumanmaleinfertility