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High-Affinity Dkk1 Receptor Kremen1 Is Internalized by Clathrin-Mediated Endocytosis

Kremens are high-affinity receptors for Dickkopf 1 (Dkk1) and regulate the Wnt/β-catenin signaling pathway by down-regulating the low-density lipoprotein receptor-related protein 6 (LRP6). Dkk1 competes with Wnt for binding to LRP6; binding of Dkk1 inhibits canonical signaling through formation of a...

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Detalles Bibliográficos
Autores principales:	Mishra, Sanjay K., Funair, Lacey, Cressley, Alex, Gittes, George K., Burns, R. Cartland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522622/ https://www.ncbi.nlm.nih.gov/pubmed/23251700 http://dx.doi.org/10.1371/journal.pone.0052190

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