Reactivation of the Tumour Suppressor RASSF1A in Breast Cancer by Simultaneous Targeting of DNA and E2F1 Methylation

BACKGROUND: Tumour suppressor genes are often transcriptionally silenced by promoter hypermethylation, and recent research has implicated alterations in chromatin structure as the mechanistic basis for this repression. In addition to DNA methylation, other epigenetic post-translational modifications...

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Detalles Bibliográficos
Autores principales: Montenegro, María F., Sáez-Ayala, Magali, Piñero-Madrona, Antonio, Cabezas-Herrera, Juan, Rodríguez-López, José Neptuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522638/
https://www.ncbi.nlm.nih.gov/pubmed/23251702
http://dx.doi.org/10.1371/journal.pone.0052231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522638/
https://www.ncbi.nlm.nih.gov/pubmed/23251702
http://dx.doi.org/10.1371/journal.pone.0052231

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