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Forkhead Box O1 Is Present in Quiescent Pituitary Cells during Development and Is Increased in the Absence of p27(Kip1)
Congenital pituitary hormone deficiencies have been reported in approximately one in 4,000 live births, however studies reporting mutations in some widely studied transcription factors account for only a fraction of congenital hormone deficiencies in humans. Anterior pituitary hormones are required...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522653/ https://www.ncbi.nlm.nih.gov/pubmed/23251696 http://dx.doi.org/10.1371/journal.pone.0052136 |
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author | Majumdar, Sreeparna Farris, Corrie L. Kabat, Brock E. Jung, Deborah O. Ellsworth, Buffy S. |
author_facet | Majumdar, Sreeparna Farris, Corrie L. Kabat, Brock E. Jung, Deborah O. Ellsworth, Buffy S. |
author_sort | Majumdar, Sreeparna |
collection | PubMed |
description | Congenital pituitary hormone deficiencies have been reported in approximately one in 4,000 live births, however studies reporting mutations in some widely studied transcription factors account for only a fraction of congenital hormone deficiencies in humans. Anterior pituitary hormones are required for development and function of several glands including gonads, adrenals, and thyroid. In order to identify additional factors that contribute to human congenital hormone deficiencies, we are investigating the forkhead transcription factor, FOXO1, which has been implicated in development of several organs including ovary, testis, and brain. We find that FOXO1 is present in the nuclei of non-dividing pituitary cells during embryonic development, consistent with a role in limiting proliferation and/or promoting differentiation. FOXO1 is present in a subset of differentiated cells at e18.5 and in adult with highest level of expression in somatotrope cells. We detected FOXO1 in p27(Kip1)-positive cells at e14.5. In the absence of p27(Kip1) the number of pituitary cells containing FOXO1 is significantly increased at e14.5 suggesting that a feedback loop regulates the interplay between FOXO1 and p27(Kip1). |
format | Online Article Text |
id | pubmed-3522653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35226532012-12-18 Forkhead Box O1 Is Present in Quiescent Pituitary Cells during Development and Is Increased in the Absence of p27(Kip1) Majumdar, Sreeparna Farris, Corrie L. Kabat, Brock E. Jung, Deborah O. Ellsworth, Buffy S. PLoS One Research Article Congenital pituitary hormone deficiencies have been reported in approximately one in 4,000 live births, however studies reporting mutations in some widely studied transcription factors account for only a fraction of congenital hormone deficiencies in humans. Anterior pituitary hormones are required for development and function of several glands including gonads, adrenals, and thyroid. In order to identify additional factors that contribute to human congenital hormone deficiencies, we are investigating the forkhead transcription factor, FOXO1, which has been implicated in development of several organs including ovary, testis, and brain. We find that FOXO1 is present in the nuclei of non-dividing pituitary cells during embryonic development, consistent with a role in limiting proliferation and/or promoting differentiation. FOXO1 is present in a subset of differentiated cells at e18.5 and in adult with highest level of expression in somatotrope cells. We detected FOXO1 in p27(Kip1)-positive cells at e14.5. In the absence of p27(Kip1) the number of pituitary cells containing FOXO1 is significantly increased at e14.5 suggesting that a feedback loop regulates the interplay between FOXO1 and p27(Kip1). Public Library of Science 2012-12-14 /pmc/articles/PMC3522653/ /pubmed/23251696 http://dx.doi.org/10.1371/journal.pone.0052136 Text en © 2012 Majumdar et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Majumdar, Sreeparna Farris, Corrie L. Kabat, Brock E. Jung, Deborah O. Ellsworth, Buffy S. Forkhead Box O1 Is Present in Quiescent Pituitary Cells during Development and Is Increased in the Absence of p27(Kip1) |
title | Forkhead Box O1 Is Present in Quiescent Pituitary Cells during Development and Is Increased in the Absence of p27(Kip1)
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title_full | Forkhead Box O1 Is Present in Quiescent Pituitary Cells during Development and Is Increased in the Absence of p27(Kip1)
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title_fullStr | Forkhead Box O1 Is Present in Quiescent Pituitary Cells during Development and Is Increased in the Absence of p27(Kip1)
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title_full_unstemmed | Forkhead Box O1 Is Present in Quiescent Pituitary Cells during Development and Is Increased in the Absence of p27(Kip1)
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title_short | Forkhead Box O1 Is Present in Quiescent Pituitary Cells during Development and Is Increased in the Absence of p27(Kip1)
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title_sort | forkhead box o1 is present in quiescent pituitary cells during development and is increased in the absence of p27(kip1) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522653/ https://www.ncbi.nlm.nih.gov/pubmed/23251696 http://dx.doi.org/10.1371/journal.pone.0052136 |
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