Cargando…

The ADNP Derived Peptide, NAP Modulates the Tubulin Pool: Implication for Neurotrophic and Neuroprotective Activities

Microtubules (MTs), key cytoskeletal elements in living cells, are critical for axonal transport, synaptic transmission, and maintenance of neuronal morphology. NAP (NAPVSIPQ) is a neuroprotective peptide derived from the essential activity-dependent neuroprotective protein (ADNP). In Alzheimer’s di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oz, Saar, Ivashko-Pachima, Yanina, Gozes, Illana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522725/ https://www.ncbi.nlm.nih.gov/pubmed/23272107 http://dx.doi.org/10.1371/journal.pone.0051458

Ejemplares similares

NAP (Davunetide): The Neuroprotective ADNP Drug Candidate Penetrates Cell Nuclei Explaining Pleiotropic Mechanisms
por: Ganaiem, Maram, et al.
Publicado: (2023)

ADNP: in search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration
por: Gozes, Illana, et al.
Publicado: (2015)

ADNP, a Microtubule Interacting Protein, Provides Neuroprotection Through End Binding Proteins and Tau: An Amplifier Effect
por: Gozes, Illana, et al.
Publicado: (2018)

Distinct Impairments Characterizing Different ADNP Mutants Reveal Aberrant Cytoplasmic-Nuclear Crosstalk
por: Ganaiem, Maram, et al.
Publicado: (2022)

A Novel Microtubule-Tau Association Enhancer and Neuroprotective Drug Candidate: Ac-SKIP
por: Ivashko-Pachima, Yanina, et al.
Publicado: (2019)

Corrigendum: A Novel Microtubule-Tau Association Enhancer and Neuroprotective Drug Candidate: Ac-SKIP
por: Ivashko-Pachima, Yanina, et al.
Publicado: (2021)

NAP (davunetide) preferential interaction with dynamic 3-repeat Tau explains differential protection in selected tauopathies
por: Ivashko-Pachima, Yanina, et al.
Publicado: (2019)

The ADNP Syndrome and CP201 (NAP) Potential and Hope
por: Gozes, Illana
Publicado: (2020)

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse
por: Sragovich, Shlomo, et al.
Publicado: (2019)

Microbiota changes associated with ADNP deficiencies: rapid indicators for NAP (CP201) treatment of the ADNP syndrome and beyond
por: Kapitansky, Oxana, et al.
Publicado: (2020)

Neuropeptide GPCRs in neuroendocrinology: the case of activity-dependent neuroprotective protein (ADNP)
por: Gozes, Illana
Publicado: (2012)

Activity-dependent neuroprotective protein (ADNP): from autism to Alzheimer’s disease
por: Gozes, Illana
Publicado: (2015)

Discovery of autism/intellectual disability somatic mutations in Alzheimer's brains: mutated ADNP cytoskeletal impairments and repair as a case study
por: Ivashko-Pachima, Yanina, et al.
Publicado: (2019)

VIP/PACAP-Based Drug Development: The ADNP/NAP-Derived Mirror Peptides SKIP and D-SKIP Exhibit Distinctive in vivo and in silico Effects
por: Sragovich, Shlomo, et al.
Publicado: (2020)

ADNP Regulates Cognition: A Multitasking Protein
por: Gozes, Illana
Publicado: (2018)

NAP and D-SAL: neuroprotection against the β amyloid peptide (1–42)
por: Gozes, Illana, et al.
Publicado: (2008)

Preventive, personalized medicine at the level of key regulatory proteins: updates on activity-dependent neuroprotective protein (ADNP) as a case study
por: Gozes, Illana
Publicado: (2014)

STOP Codon Mutations at Sites of Natural Caspase Cleavage Are Implicated in Autism and Alzheimer’s Disease: The Case of ADNP
por: Gozes, Illana, et al.
Publicado: (2022)

Novel Marker for the Onset of Frontotemporal Dementia: Early Increase in Activity-Dependent Neuroprotective Protein (ADNP) in the Face of Tau Mutation
por: Schirer, Yulie, et al.
Publicado: (2014)

Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism
por: D’Incal, Claudio Peter, et al.
Publicado: (2023)

The autism-mutated ADNP plays a key role in stress response
por: Sragovich, Shlomo, et al.
Publicado: (2019)

Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium
por: Maugeri, Grazia, et al.
Publicado: (2023)

Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium
por: Maugeri, Grazia, et al.
Publicado: (2022)

Cellular and animal models of skin alterations in the autism-related ADNP syndrome
por: Mollinedo, Pilar, et al.
Publicado: (2019)

Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer's pathologies
por: Malishkevich, A, et al.
Publicado: (2015)

Age and Sex-Dependent ADNP Regulation of Muscle Gene Expression Is Correlated with Motor Behavior: Possible Feedback Mechanism with PACAP
por: Kapitansky, Oxana, et al.
Publicado: (2020)

Single Cell ADNP Predictive of Human Muscle Disorders: Mouse Knockdown Results in Muscle Wasting
por: Kapitansky, Oxana, et al.
Publicado: (2020)

Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model
por: Vaisburd, Sinaya, et al.
Publicado: (2015)

Tauopathy in the young autistic brain: novel biomarker and therapeutic target
por: Grigg, Iris, et al.
Publicado: (2020)

Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye
por: Maugeri, Grazia, et al.
Publicado: (2022)

Tau and Caspase 3 as Targets for Neuroprotection
por: Idan-Feldman, Anat, et al.
Publicado: (2012)

Anti-Inflammatory Properties of NAP in Acute Toxoplasma Gondii-Induced Ileitis in Mice
por: Heimesaat, Markus M., et al.
Publicado: (2015)

Anti-inflammatory Effects of the Octapeptide NAP in Human Microbiota-Associated Mice Suffering from Subacute Ileitis
por: Escher, Ulrike, et al.
Publicado: (2018)

Reduction of aluminum ion neurotoxicity through a small peptide application – NAP treatment of Alzheimer’s disease
por: Yang, Ming-Hui, et al.
Publicado: (2019)

Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis
por: Heimesaat, Markus M., et al.
Publicado: (2020)

Premature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children
por: Gozes, I, et al.
Publicado: (2017)

Premature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children
por: Gozes, I, et al.
Publicado: (2017)

Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation
por: Ferreira, Ana C.F., et al.
Publicado: (2023)

ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling
por: Sun, Xiaoyun, et al.
Publicado: (2020)

Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein
por: Magen, Iddo, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_i09ronhekn101tumt8khbppeja