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Virtual Screening and Biological Evaluation of Inhibitors Targeting the XPA-ERCC1 Interaction

BACKGROUND: Nucleotide excision repair (NER) removes many types of DNA lesions including those induced by UV radiation and platinum-based therapy. Resistance to platinum-based therapy correlates with high expression of ERCC1, a major element of the NER machinery. The interaction between ERCC1 and XP...

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Detalles Bibliográficos
Autores principales:	Barakat, Khaled H., Jordheim, Lars P., Perez-Pineiro, Rolando, Wishart, David, Dumontet, Charles, Tuszynski, Jack A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522735/ https://www.ncbi.nlm.nih.gov/pubmed/23272099 http://dx.doi.org/10.1371/journal.pone.0051329

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