Personalized medicine in multiple sclerosis: hope or reality?
Personalized treatment is highly desirable in multiple sclerosis because it is an immensely heterogeneous disease. This heterogeneity is seen in both the disease course and the treatment responses. Currently, a combination of clinical features and imaging parameters in magnetic resonance imaging is...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523020/ https://www.ncbi.nlm.nih.gov/pubmed/23035757 http://dx.doi.org/10.1186/1741-7015-10-116 |
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author | Derfuss, Tobias |
author_facet | Derfuss, Tobias |
author_sort | Derfuss, Tobias |
collection | PubMed |
description | Personalized treatment is highly desirable in multiple sclerosis because it is an immensely heterogeneous disease. This heterogeneity is seen in both the disease course and the treatment responses. Currently, a combination of clinical features and imaging parameters in magnetic resonance imaging is used to classify active and non-active patients and treatment responders and non-responders. Although this classification works on a group level, individual patients often behave differently from the group. Therefore additional biomarkers are needed to provide better indicators for prognosis and treatment response. Basic and clinical research have discovered different promising targets. It is now essential to verify the utility and accuracy of these markers in large, prospectively sampled patient cohorts. |
format | Online Article Text |
id | pubmed-3523020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35230202012-12-16 Personalized medicine in multiple sclerosis: hope or reality? Derfuss, Tobias BMC Med Minireview Personalized treatment is highly desirable in multiple sclerosis because it is an immensely heterogeneous disease. This heterogeneity is seen in both the disease course and the treatment responses. Currently, a combination of clinical features and imaging parameters in magnetic resonance imaging is used to classify active and non-active patients and treatment responders and non-responders. Although this classification works on a group level, individual patients often behave differently from the group. Therefore additional biomarkers are needed to provide better indicators for prognosis and treatment response. Basic and clinical research have discovered different promising targets. It is now essential to verify the utility and accuracy of these markers in large, prospectively sampled patient cohorts. BioMed Central 2012-10-04 /pmc/articles/PMC3523020/ /pubmed/23035757 http://dx.doi.org/10.1186/1741-7015-10-116 Text en Copyright ©2012 Derfuss; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Minireview Derfuss, Tobias Personalized medicine in multiple sclerosis: hope or reality? |
title | Personalized medicine in multiple sclerosis: hope or reality? |
title_full | Personalized medicine in multiple sclerosis: hope or reality? |
title_fullStr | Personalized medicine in multiple sclerosis: hope or reality? |
title_full_unstemmed | Personalized medicine in multiple sclerosis: hope or reality? |
title_short | Personalized medicine in multiple sclerosis: hope or reality? |
title_sort | personalized medicine in multiple sclerosis: hope or reality? |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523020/ https://www.ncbi.nlm.nih.gov/pubmed/23035757 http://dx.doi.org/10.1186/1741-7015-10-116 |
work_keys_str_mv | AT derfusstobias personalizedmedicineinmultiplesclerosishopeorreality |