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The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention
Recent studies demonstrated that obesity is associated with prostate cancer aggressiveness and prognosis. However, the mechanisms underlying this relationship are poorly understood. Tumor microenvironment has been increasingly considered as an important determinant of cancer growth and progression....
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523022/ https://www.ncbi.nlm.nih.gov/pubmed/23009325 http://dx.doi.org/10.1186/1741-7015-10-109 |
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author | Lughezzani, Giovanni |
author_facet | Lughezzani, Giovanni |
author_sort | Lughezzani, Giovanni |
collection | PubMed |
description | Recent studies demonstrated that obesity is associated with prostate cancer aggressiveness and prognosis. However, the mechanisms underlying this relationship are poorly understood. Tumor microenvironment has been increasingly considered as an important determinant of cancer growth and progression. In the light of this growing evidence, Ribeiro et al., in a BMC Medicine research article, investigated the gene expression profiles of periprostatic adipose tissue of obese patients with and without prostate cancer and compared them to those of lean patients. Their findings provide the first evidence of a differential gene expression in the periprostatic adipose tissue of obese individuals. Differences were also observed when comparing the periprostatic adipose tissue of patients with and without prostate cancer. Differentially expressed genes are related to cell proliferation and immunological responses. Besides suggesting the genetic bases for the observed relationship between obesity and prostate cancer aggressiveness, these findings provide new insights on the important link between local microenvironment and cancer progression. |
format | Online Article Text |
id | pubmed-3523022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35230222012-12-16 The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention Lughezzani, Giovanni BMC Med Commentary Recent studies demonstrated that obesity is associated with prostate cancer aggressiveness and prognosis. However, the mechanisms underlying this relationship are poorly understood. Tumor microenvironment has been increasingly considered as an important determinant of cancer growth and progression. In the light of this growing evidence, Ribeiro et al., in a BMC Medicine research article, investigated the gene expression profiles of periprostatic adipose tissue of obese patients with and without prostate cancer and compared them to those of lean patients. Their findings provide the first evidence of a differential gene expression in the periprostatic adipose tissue of obese individuals. Differences were also observed when comparing the periprostatic adipose tissue of patients with and without prostate cancer. Differentially expressed genes are related to cell proliferation and immunological responses. Besides suggesting the genetic bases for the observed relationship between obesity and prostate cancer aggressiveness, these findings provide new insights on the important link between local microenvironment and cancer progression. BioMed Central 2012-09-25 /pmc/articles/PMC3523022/ /pubmed/23009325 http://dx.doi.org/10.1186/1741-7015-10-109 Text en Copyright ©2012 Lughezzani; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Commentary Lughezzani, Giovanni The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention |
title | The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention |
title_full | The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention |
title_fullStr | The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention |
title_full_unstemmed | The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention |
title_short | The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention |
title_sort | relationship between obesity and prostate cancer: from genetics to disease treatment and prevention |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523022/ https://www.ncbi.nlm.nih.gov/pubmed/23009325 http://dx.doi.org/10.1186/1741-7015-10-109 |
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