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Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses

BACKGROUND: Both the G3P[12] and the G14P[12] type of equine group A rotavirus (RVA) have recently become predominant in many countries, including Japan. G3 types are classified further into G3A and G3B. The G3A viruses have been circulating in Europe, Australia, and Argentina, and the G3B viruses h...

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Autores principales: Nemoto, Manabu, Tsunemitsu, Hiroshi, Murase, Harutaka, Nambo, Yasuo, Sato, Shinsuke, Orita, Yasuhiro, Imagawa, Hiroshi, Bannai, Hiroshi, Tsujimura, Koji, Yamanaka, Takashi, Matsumura, Tomio, Kondo, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523035/
https://www.ncbi.nlm.nih.gov/pubmed/23130609
http://dx.doi.org/10.1186/1751-0147-54-63
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author Nemoto, Manabu
Tsunemitsu, Hiroshi
Murase, Harutaka
Nambo, Yasuo
Sato, Shinsuke
Orita, Yasuhiro
Imagawa, Hiroshi
Bannai, Hiroshi
Tsujimura, Koji
Yamanaka, Takashi
Matsumura, Tomio
Kondo, Takashi
author_facet Nemoto, Manabu
Tsunemitsu, Hiroshi
Murase, Harutaka
Nambo, Yasuo
Sato, Shinsuke
Orita, Yasuhiro
Imagawa, Hiroshi
Bannai, Hiroshi
Tsujimura, Koji
Yamanaka, Takashi
Matsumura, Tomio
Kondo, Takashi
author_sort Nemoto, Manabu
collection PubMed
description BACKGROUND: Both the G3P[12] and the G14P[12] type of equine group A rotavirus (RVA) have recently become predominant in many countries, including Japan. G3 types are classified further into G3A and G3B. The G3A viruses have been circulating in Europe, Australia, and Argentina, and the G3B viruses have been circulating in Japan. However, only an inactivated vaccine containing a single G3BP[12] strain is commercially available in Japan. To assess the efficacy of the current vaccine against recently circulating equine RVA strains, we examined antibody responses in pregnant mares to recent G3BP[12] and G14P[12] strains by virus neutralization test. FINDINGS: After vaccination in five pregnant mares, the geometric mean serum titers of virus-neutralizing antibody to recent G3BP[12] strains increased 5.3- to 7.0-fold and were similar to that against homologous vaccine strain. Moreover, antibody titers to recent G14P[12] strains were also increased 3.0- to 3.5-fold. CONCLUSIONS: These results suggest that inoculation of mares with the current vaccine should provide foals with virus-neutralizing antibodies against not only the G3BP[12] but also the G14P[12] RVA strain via the colostrum.
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spelling pubmed-35230352012-12-16 Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses Nemoto, Manabu Tsunemitsu, Hiroshi Murase, Harutaka Nambo, Yasuo Sato, Shinsuke Orita, Yasuhiro Imagawa, Hiroshi Bannai, Hiroshi Tsujimura, Koji Yamanaka, Takashi Matsumura, Tomio Kondo, Takashi Acta Vet Scand Brief Communication BACKGROUND: Both the G3P[12] and the G14P[12] type of equine group A rotavirus (RVA) have recently become predominant in many countries, including Japan. G3 types are classified further into G3A and G3B. The G3A viruses have been circulating in Europe, Australia, and Argentina, and the G3B viruses have been circulating in Japan. However, only an inactivated vaccine containing a single G3BP[12] strain is commercially available in Japan. To assess the efficacy of the current vaccine against recently circulating equine RVA strains, we examined antibody responses in pregnant mares to recent G3BP[12] and G14P[12] strains by virus neutralization test. FINDINGS: After vaccination in five pregnant mares, the geometric mean serum titers of virus-neutralizing antibody to recent G3BP[12] strains increased 5.3- to 7.0-fold and were similar to that against homologous vaccine strain. Moreover, antibody titers to recent G14P[12] strains were also increased 3.0- to 3.5-fold. CONCLUSIONS: These results suggest that inoculation of mares with the current vaccine should provide foals with virus-neutralizing antibodies against not only the G3BP[12] but also the G14P[12] RVA strain via the colostrum. BioMed Central 2012-11-06 /pmc/articles/PMC3523035/ /pubmed/23130609 http://dx.doi.org/10.1186/1751-0147-54-63 Text en Copyright ©2012 Nemoto et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Nemoto, Manabu
Tsunemitsu, Hiroshi
Murase, Harutaka
Nambo, Yasuo
Sato, Shinsuke
Orita, Yasuhiro
Imagawa, Hiroshi
Bannai, Hiroshi
Tsujimura, Koji
Yamanaka, Takashi
Matsumura, Tomio
Kondo, Takashi
Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses
title Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses
title_full Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses
title_fullStr Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses
title_full_unstemmed Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses
title_short Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses
title_sort antibody response in vaccinated pregnant mares to recent g3bp[12] and g14p[12] equine rotaviruses
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523035/
https://www.ncbi.nlm.nih.gov/pubmed/23130609
http://dx.doi.org/10.1186/1751-0147-54-63
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