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Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden
BACKGROUND: Although the heritability of atrial fibrillation (AF) has been determined, the relevance of family history of AF for the likelihood of recurrent hospitalization for AF is unknown. The aim of this nationwide study was to determine whether family history of AF is a risk factor of recurrent...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523073/ https://www.ncbi.nlm.nih.gov/pubmed/23227964 http://dx.doi.org/10.1186/1471-2261-12-121 |
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author | Zöller, Bengt Ohlsson, Henrik Sundquist, Jan Sundquist, Kristina |
author_facet | Zöller, Bengt Ohlsson, Henrik Sundquist, Jan Sundquist, Kristina |
author_sort | Zöller, Bengt |
collection | PubMed |
description | BACKGROUND: Although the heritability of atrial fibrillation (AF) has been determined, the relevance of family history of AF for the likelihood of recurrent hospitalization for AF is unknown. The aim of this nationwide study was to determine whether family history of AF is a risk factor of recurrent hospitalization for lone AF (LAF), i.e., AF with unknown etiology. The familial risk for first time LAF hospitalization was also determined and compared to the risk of recurrent hospitalization for LAF. METHODS: We examined whether family history of AF is a risk factor for recurrent hospitalization for LAF in the whole Swedish population. We linked Multigeneration Register data on individuals aged 0–60 years to Hospital Discharge Register data for the period 1987–2009 to compare LAF recurrent hospitalization risk among individuals with and without parental or sibling history of AF. We calculated hazard ratios (HRs) to determine the familial HR of recurrent hospitalization for LAF. Odds ratios (OR) were calculated for familial risk of first time LAF hospitalization. RESULTS: The risk of recurrent LAF hospitalization was 1.23 (95% CI 1.17-1.30) for individuals with affected parents compared to 1.30 (95% CI 1.22-1.38) for those with affected siblings. After 10 years of follow up 50% of those without and 60% of those with family history had recurrent hospitalization for LAF. The risk of recurrent LAF hospitalization in individuals with two affected parents was 1.65 (95% CI 1.44-1.90). There was an interaction between age and family history, with family history having a weaker effect on LAF hospitalization risk in older age groups. The OR for first time LAF hospitalization was 2.08 (95% CI 2.02-2.15) for offspring with affected parents and 3.23 (95% CI 3.08-3.39) for individuals with affected siblings. CONCLUSIONS: Family history of AF is a novel risk factor for recurrent LAF hospitalization. The higher recurrence hospitalization risk in multiplex families and younger individuals suggests a genetic contribution. However, the familial risk for recurrent LAF hospitalization was much lower than the risk for first time LAF hospitalization, suggesting that familial and possibly genetic factors are more important for first time LAF hospitalization than recurrent LAF hospitalization. |
format | Online Article Text |
id | pubmed-3523073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35230732012-12-16 Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden Zöller, Bengt Ohlsson, Henrik Sundquist, Jan Sundquist, Kristina BMC Cardiovasc Disord Research Article BACKGROUND: Although the heritability of atrial fibrillation (AF) has been determined, the relevance of family history of AF for the likelihood of recurrent hospitalization for AF is unknown. The aim of this nationwide study was to determine whether family history of AF is a risk factor of recurrent hospitalization for lone AF (LAF), i.e., AF with unknown etiology. The familial risk for first time LAF hospitalization was also determined and compared to the risk of recurrent hospitalization for LAF. METHODS: We examined whether family history of AF is a risk factor for recurrent hospitalization for LAF in the whole Swedish population. We linked Multigeneration Register data on individuals aged 0–60 years to Hospital Discharge Register data for the period 1987–2009 to compare LAF recurrent hospitalization risk among individuals with and without parental or sibling history of AF. We calculated hazard ratios (HRs) to determine the familial HR of recurrent hospitalization for LAF. Odds ratios (OR) were calculated for familial risk of first time LAF hospitalization. RESULTS: The risk of recurrent LAF hospitalization was 1.23 (95% CI 1.17-1.30) for individuals with affected parents compared to 1.30 (95% CI 1.22-1.38) for those with affected siblings. After 10 years of follow up 50% of those without and 60% of those with family history had recurrent hospitalization for LAF. The risk of recurrent LAF hospitalization in individuals with two affected parents was 1.65 (95% CI 1.44-1.90). There was an interaction between age and family history, with family history having a weaker effect on LAF hospitalization risk in older age groups. The OR for first time LAF hospitalization was 2.08 (95% CI 2.02-2.15) for offspring with affected parents and 3.23 (95% CI 3.08-3.39) for individuals with affected siblings. CONCLUSIONS: Family history of AF is a novel risk factor for recurrent LAF hospitalization. The higher recurrence hospitalization risk in multiplex families and younger individuals suggests a genetic contribution. However, the familial risk for recurrent LAF hospitalization was much lower than the risk for first time LAF hospitalization, suggesting that familial and possibly genetic factors are more important for first time LAF hospitalization than recurrent LAF hospitalization. BioMed Central 2012-12-10 /pmc/articles/PMC3523073/ /pubmed/23227964 http://dx.doi.org/10.1186/1471-2261-12-121 Text en Copyright ©2012 Zoller et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zöller, Bengt Ohlsson, Henrik Sundquist, Jan Sundquist, Kristina Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden |
title | Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden |
title_full | Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden |
title_fullStr | Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden |
title_full_unstemmed | Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden |
title_short | Family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in Sweden |
title_sort | family history as a risk factor for recurrent hospitalization for lone atrial fibrillation: a nationwide family study in sweden |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523073/ https://www.ncbi.nlm.nih.gov/pubmed/23227964 http://dx.doi.org/10.1186/1471-2261-12-121 |
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