Cargando…

Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction

Hydrogen sulfide (H(2)S) has historically been considered to be a toxic gas, an environmental and occupational hazard. However, with the discovery of its presence and enzymatic production through precursors of L-cysteine and homocysteine in mammalian tissues, H(2)S has recently received much interes...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Wei, Kan, Jun-tao, Cheng, Ze-yu, Chen, Jie-fang, Shen, Ya-qi, Xu, Jie, Wu, Dan, Zhu, Yi-zhun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523162/
https://www.ncbi.nlm.nih.gov/pubmed/23304257
http://dx.doi.org/10.1155/2012/878052
Descripción
Sumario:Hydrogen sulfide (H(2)S) has historically been considered to be a toxic gas, an environmental and occupational hazard. However, with the discovery of its presence and enzymatic production through precursors of L-cysteine and homocysteine in mammalian tissues, H(2)S has recently received much interest as a physiological signaling molecule. H(2)S is a gaseous messenger molecule that has been implicated in various physiological and pathological processes in mammals, including vascular relaxation, angiogenesis, and the function of ion channels, ischemia/reperfusion (I/R), and heart injury. H(2)S is an endogenous neuromodulator and present studies show that physiological concentrations of H(2)S enhance NMDA receptor-mediated responses and aid in the induction of hippocampal long-term potentiation. Moreover, in the field of neuronal protection, physiological concentrations of H(2)S in mitochondria have many favorable effects on cytoprotection.