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Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction
Hydrogen sulfide (H(2)S) has historically been considered to be a toxic gas, an environmental and occupational hazard. However, with the discovery of its presence and enzymatic production through precursors of L-cysteine and homocysteine in mammalian tissues, H(2)S has recently received much interes...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523162/ https://www.ncbi.nlm.nih.gov/pubmed/23304257 http://dx.doi.org/10.1155/2012/878052 |
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author | Guo, Wei Kan, Jun-tao Cheng, Ze-yu Chen, Jie-fang Shen, Ya-qi Xu, Jie Wu, Dan Zhu, Yi-zhun |
author_facet | Guo, Wei Kan, Jun-tao Cheng, Ze-yu Chen, Jie-fang Shen, Ya-qi Xu, Jie Wu, Dan Zhu, Yi-zhun |
author_sort | Guo, Wei |
collection | PubMed |
description | Hydrogen sulfide (H(2)S) has historically been considered to be a toxic gas, an environmental and occupational hazard. However, with the discovery of its presence and enzymatic production through precursors of L-cysteine and homocysteine in mammalian tissues, H(2)S has recently received much interest as a physiological signaling molecule. H(2)S is a gaseous messenger molecule that has been implicated in various physiological and pathological processes in mammals, including vascular relaxation, angiogenesis, and the function of ion channels, ischemia/reperfusion (I/R), and heart injury. H(2)S is an endogenous neuromodulator and present studies show that physiological concentrations of H(2)S enhance NMDA receptor-mediated responses and aid in the induction of hippocampal long-term potentiation. Moreover, in the field of neuronal protection, physiological concentrations of H(2)S in mitochondria have many favorable effects on cytoprotection. |
format | Online Article Text |
id | pubmed-3523162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35231622013-01-09 Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction Guo, Wei Kan, Jun-tao Cheng, Ze-yu Chen, Jie-fang Shen, Ya-qi Xu, Jie Wu, Dan Zhu, Yi-zhun Oxid Med Cell Longev Review Article Hydrogen sulfide (H(2)S) has historically been considered to be a toxic gas, an environmental and occupational hazard. However, with the discovery of its presence and enzymatic production through precursors of L-cysteine and homocysteine in mammalian tissues, H(2)S has recently received much interest as a physiological signaling molecule. H(2)S is a gaseous messenger molecule that has been implicated in various physiological and pathological processes in mammals, including vascular relaxation, angiogenesis, and the function of ion channels, ischemia/reperfusion (I/R), and heart injury. H(2)S is an endogenous neuromodulator and present studies show that physiological concentrations of H(2)S enhance NMDA receptor-mediated responses and aid in the induction of hippocampal long-term potentiation. Moreover, in the field of neuronal protection, physiological concentrations of H(2)S in mitochondria have many favorable effects on cytoprotection. Hindawi Publishing Corporation 2012 2012-12-05 /pmc/articles/PMC3523162/ /pubmed/23304257 http://dx.doi.org/10.1155/2012/878052 Text en Copyright © 2012 Wei Guo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Guo, Wei Kan, Jun-tao Cheng, Ze-yu Chen, Jie-fang Shen, Ya-qi Xu, Jie Wu, Dan Zhu, Yi-zhun Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction |
title | Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction |
title_full | Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction |
title_fullStr | Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction |
title_full_unstemmed | Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction |
title_short | Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction |
title_sort | hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523162/ https://www.ncbi.nlm.nih.gov/pubmed/23304257 http://dx.doi.org/10.1155/2012/878052 |
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