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Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film
Purpose. Based on the experiment of the microarteriogenesis that is associated with angiogenesis during tissue repair process in porous silk fibroin films (PSFFs), we investigate the characteristics of micro-arteriogenesis and explore its mechanism. Methods. After the porous silk fibroin materials a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523163/ https://www.ncbi.nlm.nih.gov/pubmed/23304150 http://dx.doi.org/10.1155/2012/262890 |
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author | Bai, Lun Wang, Guangqian Tan, Xiaoyan Xu, Jianmei |
author_facet | Bai, Lun Wang, Guangqian Tan, Xiaoyan Xu, Jianmei |
author_sort | Bai, Lun |
collection | PubMed |
description | Purpose. Based on the experiment of the microarteriogenesis that is associated with angiogenesis during tissue repair process in porous silk fibroin films (PSFFs), we investigate the characteristics of micro-arteriogenesis and explore its mechanism. Methods. After the porous silk fibroin materials are implanted into the back hypodermal tissue of SD rats, the arteriole development and the morphogenesis of smooth muscle cell are histologically monitored and the micro-arteriogenesis is quantitatively analyzed. Results. 10 days after implantation, the arteriole density reaches the highest level in the junction of silk fibroin materials with tissues. Three weeks later, the arteriolar density in the materials reaches the maximum, and the arterioles in the junction of materials with tissues appear to be in a mature and upgrading state. Modeling of Microarteriogenesis. The arterioles in materials are generated after capillary angiogenesis. It is inferred that arteriolar development does not start until the network of the capillaries is formed. At first, the arterioles grow in the conjunct area of precapillaries with arterioles. Then with the extension of the arterioles, the upgrade of arterioles in connecting area is observed at a later stage. Based on the observation, the conditions and the mechanism of microarterializations as well as the upgrade of arterioles are analyzed. |
format | Online Article Text |
id | pubmed-3523163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35231632013-01-09 Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film Bai, Lun Wang, Guangqian Tan, Xiaoyan Xu, Jianmei Int J Biomater Research Article Purpose. Based on the experiment of the microarteriogenesis that is associated with angiogenesis during tissue repair process in porous silk fibroin films (PSFFs), we investigate the characteristics of micro-arteriogenesis and explore its mechanism. Methods. After the porous silk fibroin materials are implanted into the back hypodermal tissue of SD rats, the arteriole development and the morphogenesis of smooth muscle cell are histologically monitored and the micro-arteriogenesis is quantitatively analyzed. Results. 10 days after implantation, the arteriole density reaches the highest level in the junction of silk fibroin materials with tissues. Three weeks later, the arteriolar density in the materials reaches the maximum, and the arterioles in the junction of materials with tissues appear to be in a mature and upgrading state. Modeling of Microarteriogenesis. The arterioles in materials are generated after capillary angiogenesis. It is inferred that arteriolar development does not start until the network of the capillaries is formed. At first, the arterioles grow in the conjunct area of precapillaries with arterioles. Then with the extension of the arterioles, the upgrade of arterioles in connecting area is observed at a later stage. Based on the observation, the conditions and the mechanism of microarterializations as well as the upgrade of arterioles are analyzed. Hindawi Publishing Corporation 2012 2012-12-05 /pmc/articles/PMC3523163/ /pubmed/23304150 http://dx.doi.org/10.1155/2012/262890 Text en Copyright © 2012 Lun Bai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bai, Lun Wang, Guangqian Tan, Xiaoyan Xu, Jianmei Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
title | Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
title_full | Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
title_fullStr | Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
title_full_unstemmed | Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
title_short | Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
title_sort | exploring the mechanism of microarteriogenesis in porous silk fibroin film |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523163/ https://www.ncbi.nlm.nih.gov/pubmed/23304150 http://dx.doi.org/10.1155/2012/262890 |
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