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The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages

Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheuma...

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Detalles Bibliográficos
Autores principales: Yu, Tao, Yi, Young-Su, Yang, Yanyan, Oh, Jueun, Jeong, Deok, Cho, Jae Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523167/
https://www.ncbi.nlm.nih.gov/pubmed/23304064
http://dx.doi.org/10.1155/2012/979105
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author Yu, Tao
Yi, Young-Su
Yang, Yanyan
Oh, Jueun
Jeong, Deok
Cho, Jae Youl
author_facet Yu, Tao
Yi, Young-Su
Yang, Yanyan
Oh, Jueun
Jeong, Deok
Cho, Jae Youl
author_sort Yu, Tao
collection PubMed
description Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. Recently, an increasing number of studies have focused on inflammatory diseases. TBK1 is a serine/threonine-protein kinase which regulates antiviral defense, host-virus interaction, and immunity. It is ubiquitously expressed in mouse stomach, colon, thymus, and liver. Interestingly, high levels of active TBK1 have also been found to be associated with inflammatory diseases, indicating that TBK1 is closely related to inflammatory responses. Even though relatively few studies have addressed the functional roles of TBK1 relating to inflammation, this paper discusses some recent findings that support the critical role of TBK1 in inflammatory diseases and underlie the necessity of trials to develop useful remedies or therapeutics that target TBK1 for the treatment of inflammatory diseases.
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spelling pubmed-35231672013-01-09 The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages Yu, Tao Yi, Young-Su Yang, Yanyan Oh, Jueun Jeong, Deok Cho, Jae Youl Mediators Inflamm Review Article Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. Recently, an increasing number of studies have focused on inflammatory diseases. TBK1 is a serine/threonine-protein kinase which regulates antiviral defense, host-virus interaction, and immunity. It is ubiquitously expressed in mouse stomach, colon, thymus, and liver. Interestingly, high levels of active TBK1 have also been found to be associated with inflammatory diseases, indicating that TBK1 is closely related to inflammatory responses. Even though relatively few studies have addressed the functional roles of TBK1 relating to inflammation, this paper discusses some recent findings that support the critical role of TBK1 in inflammatory diseases and underlie the necessity of trials to develop useful remedies or therapeutics that target TBK1 for the treatment of inflammatory diseases. Hindawi Publishing Corporation 2012 2012-12-06 /pmc/articles/PMC3523167/ /pubmed/23304064 http://dx.doi.org/10.1155/2012/979105 Text en Copyright © 2012 Tao Yu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yu, Tao
Yi, Young-Su
Yang, Yanyan
Oh, Jueun
Jeong, Deok
Cho, Jae Youl
The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages
title The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages
title_full The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages
title_fullStr The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages
title_full_unstemmed The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages
title_short The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages
title_sort pivotal role of tbk1 in inflammatory responses mediated by macrophages
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523167/
https://www.ncbi.nlm.nih.gov/pubmed/23304064
http://dx.doi.org/10.1155/2012/979105
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