Cargando…
The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages
Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheuma...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523167/ https://www.ncbi.nlm.nih.gov/pubmed/23304064 http://dx.doi.org/10.1155/2012/979105 |
_version_ | 1782253185062141952 |
---|---|
author | Yu, Tao Yi, Young-Su Yang, Yanyan Oh, Jueun Jeong, Deok Cho, Jae Youl |
author_facet | Yu, Tao Yi, Young-Su Yang, Yanyan Oh, Jueun Jeong, Deok Cho, Jae Youl |
author_sort | Yu, Tao |
collection | PubMed |
description | Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. Recently, an increasing number of studies have focused on inflammatory diseases. TBK1 is a serine/threonine-protein kinase which regulates antiviral defense, host-virus interaction, and immunity. It is ubiquitously expressed in mouse stomach, colon, thymus, and liver. Interestingly, high levels of active TBK1 have also been found to be associated with inflammatory diseases, indicating that TBK1 is closely related to inflammatory responses. Even though relatively few studies have addressed the functional roles of TBK1 relating to inflammation, this paper discusses some recent findings that support the critical role of TBK1 in inflammatory diseases and underlie the necessity of trials to develop useful remedies or therapeutics that target TBK1 for the treatment of inflammatory diseases. |
format | Online Article Text |
id | pubmed-3523167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35231672013-01-09 The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages Yu, Tao Yi, Young-Su Yang, Yanyan Oh, Jueun Jeong, Deok Cho, Jae Youl Mediators Inflamm Review Article Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. Recently, an increasing number of studies have focused on inflammatory diseases. TBK1 is a serine/threonine-protein kinase which regulates antiviral defense, host-virus interaction, and immunity. It is ubiquitously expressed in mouse stomach, colon, thymus, and liver. Interestingly, high levels of active TBK1 have also been found to be associated with inflammatory diseases, indicating that TBK1 is closely related to inflammatory responses. Even though relatively few studies have addressed the functional roles of TBK1 relating to inflammation, this paper discusses some recent findings that support the critical role of TBK1 in inflammatory diseases and underlie the necessity of trials to develop useful remedies or therapeutics that target TBK1 for the treatment of inflammatory diseases. Hindawi Publishing Corporation 2012 2012-12-06 /pmc/articles/PMC3523167/ /pubmed/23304064 http://dx.doi.org/10.1155/2012/979105 Text en Copyright © 2012 Tao Yu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yu, Tao Yi, Young-Su Yang, Yanyan Oh, Jueun Jeong, Deok Cho, Jae Youl The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
title | The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
title_full | The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
title_fullStr | The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
title_full_unstemmed | The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
title_short | The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
title_sort | pivotal role of tbk1 in inflammatory responses mediated by macrophages |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523167/ https://www.ncbi.nlm.nih.gov/pubmed/23304064 http://dx.doi.org/10.1155/2012/979105 |
work_keys_str_mv | AT yutao thepivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT yiyoungsu thepivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT yangyanyan thepivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT ohjueun thepivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT jeongdeok thepivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT chojaeyoul thepivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT yutao pivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT yiyoungsu pivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT yangyanyan pivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT ohjueun pivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT jeongdeok pivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages AT chojaeyoul pivotalroleoftbk1ininflammatoryresponsesmediatedbymacrophages |