Crystal structure of the μ-opioid receptor bound to a morphinan antagonist

Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to relieve severe pain. These prototypical opioids produce analgesia as well as many of their undesirable side effects (sedation, apnea and dependence) by binding to and activati...

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Detalles Bibliográficos
Autores principales: Manglik, Aashish, Kruse, Andrew C., Kobilka, Tong Sun, Thian, Foon Sun, Mathiesen, Jesper M., Sunahara, Roger K., Pardo, Leonardo, Weis, William I., Kobilka, Brian K., Granier, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523197/
https://www.ncbi.nlm.nih.gov/pubmed/22437502
http://dx.doi.org/10.1038/nature10954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523197/
https://www.ncbi.nlm.nih.gov/pubmed/22437502
http://dx.doi.org/10.1038/nature10954

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