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Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target

Neuropeptides acting on specific cell membrane receptors of the G protein-coupled receptor (GPCR) superfamily regulate a range of important aspects of nervous and neuroendocrine function. Gastrin-releasing peptide (GRP) is a mammalian neuropeptide that binds to the GRP receptor (GRPR, BB2). Increasi...

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Detalles Bibliográficos
Autores principales: Roesler, Rafael, Schwartsmann, Gilberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523293/
https://www.ncbi.nlm.nih.gov/pubmed/23251133
http://dx.doi.org/10.3389/fendo.2012.00159
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author Roesler, Rafael
Schwartsmann, Gilberto
author_facet Roesler, Rafael
Schwartsmann, Gilberto
author_sort Roesler, Rafael
collection PubMed
description Neuropeptides acting on specific cell membrane receptors of the G protein-coupled receptor (GPCR) superfamily regulate a range of important aspects of nervous and neuroendocrine function. Gastrin-releasing peptide (GRP) is a mammalian neuropeptide that binds to the GRP receptor (GRPR, BB2). Increasing evidence indicates that GRPR-mediated signaling in the central nervous system (CNS) plays an important role in regulating brain function, including aspects related to emotional responses, social interaction, memory, and feeding behavior. In addition, some alterations in GRP or GRPR expression or function have been described in patients with neurodegenerative, neurodevelopmental, and psychiatric disorders, as well as in brain tumors. Findings from preclinical models are consistent with the view that the GRPR might play a role in brain disorders, and raise the possibility that GRPR agonists might ameliorate cognitive and social deficits associated with neurological diseases, while antagonists may reduce anxiety and inhibit the growth of some types of brain cancer. Further preclinical and translational studies evaluating the potential therapeutic effects of GRPR ligands are warranted.
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spelling pubmed-35232932012-12-18 Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target Roesler, Rafael Schwartsmann, Gilberto Front Endocrinol (Lausanne) Endocrinology Neuropeptides acting on specific cell membrane receptors of the G protein-coupled receptor (GPCR) superfamily regulate a range of important aspects of nervous and neuroendocrine function. Gastrin-releasing peptide (GRP) is a mammalian neuropeptide that binds to the GRP receptor (GRPR, BB2). Increasing evidence indicates that GRPR-mediated signaling in the central nervous system (CNS) plays an important role in regulating brain function, including aspects related to emotional responses, social interaction, memory, and feeding behavior. In addition, some alterations in GRP or GRPR expression or function have been described in patients with neurodegenerative, neurodevelopmental, and psychiatric disorders, as well as in brain tumors. Findings from preclinical models are consistent with the view that the GRPR might play a role in brain disorders, and raise the possibility that GRPR agonists might ameliorate cognitive and social deficits associated with neurological diseases, while antagonists may reduce anxiety and inhibit the growth of some types of brain cancer. Further preclinical and translational studies evaluating the potential therapeutic effects of GRPR ligands are warranted. Frontiers Media S.A. 2012-12-17 /pmc/articles/PMC3523293/ /pubmed/23251133 http://dx.doi.org/10.3389/fendo.2012.00159 Text en Copyright © Roesler and Schwartsmann. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Endocrinology
Roesler, Rafael
Schwartsmann, Gilberto
Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target
title Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target
title_full Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target
title_fullStr Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target
title_full_unstemmed Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target
title_short Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target
title_sort gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523293/
https://www.ncbi.nlm.nih.gov/pubmed/23251133
http://dx.doi.org/10.3389/fendo.2012.00159
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