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CD4 binding determinant mimicry for HIV vaccine design

The immunodominant epitopes expressed by the HIV-1 envelope protein gp120 are hypermutable, defeating attempts to develop an effective HIV vaccine. Targeting the structurally conserved gp120 determinant that binds host CD4 receptors (CD4BD) and initiates infection is a more promising route to vaccin...

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Detalles Bibliográficos
Autores principales:	Nishiyama, Yasuhiro, Planque, Stephanie, Hanson, Carl V., Massey, Richard J., Paul, Sudhir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2012
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523313/ https://www.ncbi.nlm.nih.gov/pubmed/23251137 http://dx.doi.org/10.3389/fimmu.2012.00383

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