Selective FLT3 inhibition of FLT3-ITD(+) acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Acquired resistance to selective FLT3 inhibitors, is an emerging clinical problem in the treatment of FLT3-ITD(+) acute myeloid leukaemia (AML). The paucity of valid pre-clinical models has limited investigations to determine the mechanism of acquired therapeutic resistance, thereby limiting the dev...

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Detalles Bibliográficos
Autores principales: Moore, Andrew S., Faisal, Amir, de Castro, David Gonzalez, Bavetsias, Vassilios, Sun, Chongbo, Atrash, Butrus, Valenti, Melanie, de Haven Brandon, Alexis, Avery, Sian, Mair, Debbie, Mirabella, Fabio, Swansbury, John, Pearson, Andrew D.J., Workman, Paul, Blagg, Julian, Raynaud, Florence I., Eccles, Suzanne A., Linardopoulos, Spiros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523391/
https://www.ncbi.nlm.nih.gov/pubmed/22354205
http://dx.doi.org/10.1038/leu.2012.52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523391/
https://www.ncbi.nlm.nih.gov/pubmed/22354205
http://dx.doi.org/10.1038/leu.2012.52

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