Pediatric glioblastoma multiforme: A single-institution experience

BACKGROUND: Glioblastoma multiforme (GBM) is the most common astrocytoma in adults and has a poor prognosis, with a median survival of about 12 months. But, it is rare in children. We report our experience on the pediatric population (20 years or younger) with GBM. PATIENTS AND METHODS: Twenty-three...

Descripción completa

Detalles Bibliográficos
Autores principales: Ansari, Mansour, Nasrolahi, Hamid, Kani, Amir-Abbas, Mohammadianpanah, Mohammad, Ahmadloo, Niloofar, Omidvari, Shapour, Mosalaei, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523472/
https://www.ncbi.nlm.nih.gov/pubmed/23248421
http://dx.doi.org/10.4103/0971-5851.103142
Descripción
Sumario:BACKGROUND: Glioblastoma multiforme (GBM) is the most common astrocytoma in adults and has a poor prognosis, with a median survival of about 12 months. But, it is rare in children. We report our experience on the pediatric population (20 years or younger) with GBM. PATIENTS AND METHODS: Twenty-three patients with GBM who were treated at our hospital during 1990–2008 were evaluated. RESULTS: The mean age was 15.2 years, and the majority of them (14/23) were male. All had received radiotherapy and some had also received chemotherapy. The mean survival was 16.0 months. Two cases survived more than 5 years. Age, radiation dose and performance status were significantly related to survival. CONCLUSION: GBM in pediatric patients were not very common in our center, and prognosis was unfavorable.

Ejemplares similares