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Analgesic effects of stem bark extracts of Trichilia monadelpha (Thonn.) JJ De Wilde
OBJECTIVES: Various parts of Trichilia monadelpha (Thonn) JJ De Wilde (Fam. Meliaceae) are used in Ghanaian traditional medicine for the treatment of painful and inflammatory conditions. The present study examined the analgesic properties of the petroleum ether (PEE), ethyl acetate (EAE), and the hy...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523507/ https://www.ncbi.nlm.nih.gov/pubmed/23248409 http://dx.doi.org/10.4103/0253-7613.103299 |
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author | Woode, Eric Amoh-Barimah, Ama Kyeraa Abotsi, Wonder Kofi Mensah Ainooson, George Kwaw Owusu, George |
author_facet | Woode, Eric Amoh-Barimah, Ama Kyeraa Abotsi, Wonder Kofi Mensah Ainooson, George Kwaw Owusu, George |
author_sort | Woode, Eric |
collection | PubMed |
description | OBJECTIVES: Various parts of Trichilia monadelpha (Thonn) JJ De Wilde (Fam. Meliaceae) are used in Ghanaian traditional medicine for the treatment of painful and inflammatory conditions. The present study examined the analgesic properties of the petroleum ether (PEE), ethyl acetate (EAE), and the hydro-ethanolic (HAE) extract of the stem bark of the plant in murine models. MATERIALS AND METHODS: PEE, EAE, and HAE were assessed in chemical (acetic acid-induced abdominal writhing and formalin tests), thermal (hot plate test), and mechanical (Randall-Selitto paw pressure test) pain models. The possible mechanisms of the antinociceptive action were also examined with various antagonists in the formalin test. RESULTS: HAE, EAE, and PEE, each at doses of 10–100 mg/kg orally, and the positive controls (morphine and diclofenac) elicited significant dose-dependent antinociceptive activity in the chemical (acetic acid abdominal writhing and formalin tests), thermal (hot plate test), and mechanical (Randall-Selitto paw pressure test) pain models in rodents. The antinociceptive effect of HAE was partly or wholly reversed by systemic administration of atropine, naloxone, and glibenclamide. The antinociceptive effects of EAE and PEE were inhibited by atropine. CONCLUSION: The extracts HAE, EAE, and PEE caused dose-related antinociception in chemical, thermal, and mechanical models of pain in animals. The mechanism of action of HAE involves an interaction with muscarinic cholinergic, adenosinergic, opioidergic pathways, and ATP-sensitive K(+) channels while that of EAE and PEE involve the muscarinic cholinergic system. |
format | Online Article Text |
id | pubmed-3523507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-35235072012-12-17 Analgesic effects of stem bark extracts of Trichilia monadelpha (Thonn.) JJ De Wilde Woode, Eric Amoh-Barimah, Ama Kyeraa Abotsi, Wonder Kofi Mensah Ainooson, George Kwaw Owusu, George Indian J Pharmacol Research Article OBJECTIVES: Various parts of Trichilia monadelpha (Thonn) JJ De Wilde (Fam. Meliaceae) are used in Ghanaian traditional medicine for the treatment of painful and inflammatory conditions. The present study examined the analgesic properties of the petroleum ether (PEE), ethyl acetate (EAE), and the hydro-ethanolic (HAE) extract of the stem bark of the plant in murine models. MATERIALS AND METHODS: PEE, EAE, and HAE were assessed in chemical (acetic acid-induced abdominal writhing and formalin tests), thermal (hot plate test), and mechanical (Randall-Selitto paw pressure test) pain models. The possible mechanisms of the antinociceptive action were also examined with various antagonists in the formalin test. RESULTS: HAE, EAE, and PEE, each at doses of 10–100 mg/kg orally, and the positive controls (morphine and diclofenac) elicited significant dose-dependent antinociceptive activity in the chemical (acetic acid abdominal writhing and formalin tests), thermal (hot plate test), and mechanical (Randall-Selitto paw pressure test) pain models in rodents. The antinociceptive effect of HAE was partly or wholly reversed by systemic administration of atropine, naloxone, and glibenclamide. The antinociceptive effects of EAE and PEE were inhibited by atropine. CONCLUSION: The extracts HAE, EAE, and PEE caused dose-related antinociception in chemical, thermal, and mechanical models of pain in animals. The mechanism of action of HAE involves an interaction with muscarinic cholinergic, adenosinergic, opioidergic pathways, and ATP-sensitive K(+) channels while that of EAE and PEE involve the muscarinic cholinergic system. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3523507/ /pubmed/23248409 http://dx.doi.org/10.4103/0253-7613.103299 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Woode, Eric Amoh-Barimah, Ama Kyeraa Abotsi, Wonder Kofi Mensah Ainooson, George Kwaw Owusu, George Analgesic effects of stem bark extracts of Trichilia monadelpha (Thonn.) JJ De Wilde |
title | Analgesic effects of stem bark extracts of Trichilia monadelpha (Thonn.) JJ De Wilde |
title_full | Analgesic effects of stem bark extracts of Trichilia monadelpha (Thonn.) JJ De Wilde |
title_fullStr | Analgesic effects of stem bark extracts of Trichilia monadelpha (Thonn.) JJ De Wilde |
title_full_unstemmed | Analgesic effects of stem bark extracts of Trichilia monadelpha (Thonn.) JJ De Wilde |
title_short | Analgesic effects of stem bark extracts of Trichilia monadelpha (Thonn.) JJ De Wilde |
title_sort | analgesic effects of stem bark extracts of trichilia monadelpha (thonn.) jj de wilde |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523507/ https://www.ncbi.nlm.nih.gov/pubmed/23248409 http://dx.doi.org/10.4103/0253-7613.103299 |
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