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Radioprotective property of an aqueous extract from valeriana wallichii

OBJECTIVES: Preparations of herbal drugs have drawn considerable interest in scientific community in recent years for the treatment of several stress related health problems including radiation-injury. MATERIALS AND METHODS: An aqueous extract from Valeriana wallichii containing hesperidin as one of...

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Detalles Bibliográficos
Autores principales: Katoch, Omika, Kaushik, Shikha, Kumar, Mysore Sadashiv Yogendra, Agrawala, Paban K., Misra, Kshipra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523530/
https://www.ncbi.nlm.nih.gov/pubmed/23248568
http://dx.doi.org/10.4103/0975-7406.103272
Descripción
Sumario:OBJECTIVES: Preparations of herbal drugs have drawn considerable interest in scientific community in recent years for the treatment of several stress related health problems including radiation-injury. MATERIALS AND METHODS: An aqueous extract from Valeriana wallichii containing hesperidin as one of its major constituent was evaluated for its ability to protect against radiation-injury in model systems like plasmid deoxyribonucleic acid (DNA) and cultured human fibroblast cells. RESULTS: The extract was found to significantly counter radiation-induced free radicals at 4 h after 5 Gy irradiation, reduced prolonged oxidative stress led increase in mitochondrial mass, enhanced reproductive viability of cultured cells and protected against radiation-induced DNA damage in solution. DISCUSSION: Further studies are required to validate the radioprotective ability of the extract and to develop a safer radioprotective agent.