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Radioprotective property of an aqueous extract from valeriana wallichii
OBJECTIVES: Preparations of herbal drugs have drawn considerable interest in scientific community in recent years for the treatment of several stress related health problems including radiation-injury. MATERIALS AND METHODS: An aqueous extract from Valeriana wallichii containing hesperidin as one of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523530/ https://www.ncbi.nlm.nih.gov/pubmed/23248568 http://dx.doi.org/10.4103/0975-7406.103272 |
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author | Katoch, Omika Kaushik, Shikha Kumar, Mysore Sadashiv Yogendra Agrawala, Paban K. Misra, Kshipra |
author_facet | Katoch, Omika Kaushik, Shikha Kumar, Mysore Sadashiv Yogendra Agrawala, Paban K. Misra, Kshipra |
author_sort | Katoch, Omika |
collection | PubMed |
description | OBJECTIVES: Preparations of herbal drugs have drawn considerable interest in scientific community in recent years for the treatment of several stress related health problems including radiation-injury. MATERIALS AND METHODS: An aqueous extract from Valeriana wallichii containing hesperidin as one of its major constituent was evaluated for its ability to protect against radiation-injury in model systems like plasmid deoxyribonucleic acid (DNA) and cultured human fibroblast cells. RESULTS: The extract was found to significantly counter radiation-induced free radicals at 4 h after 5 Gy irradiation, reduced prolonged oxidative stress led increase in mitochondrial mass, enhanced reproductive viability of cultured cells and protected against radiation-induced DNA damage in solution. DISCUSSION: Further studies are required to validate the radioprotective ability of the extract and to develop a safer radioprotective agent. |
format | Online Article Text |
id | pubmed-3523530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-35235302012-12-17 Radioprotective property of an aqueous extract from valeriana wallichii Katoch, Omika Kaushik, Shikha Kumar, Mysore Sadashiv Yogendra Agrawala, Paban K. Misra, Kshipra J Pharm Bioallied Sci Original Article OBJECTIVES: Preparations of herbal drugs have drawn considerable interest in scientific community in recent years for the treatment of several stress related health problems including radiation-injury. MATERIALS AND METHODS: An aqueous extract from Valeriana wallichii containing hesperidin as one of its major constituent was evaluated for its ability to protect against radiation-injury in model systems like plasmid deoxyribonucleic acid (DNA) and cultured human fibroblast cells. RESULTS: The extract was found to significantly counter radiation-induced free radicals at 4 h after 5 Gy irradiation, reduced prolonged oxidative stress led increase in mitochondrial mass, enhanced reproductive viability of cultured cells and protected against radiation-induced DNA damage in solution. DISCUSSION: Further studies are required to validate the radioprotective ability of the extract and to develop a safer radioprotective agent. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3523530/ /pubmed/23248568 http://dx.doi.org/10.4103/0975-7406.103272 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Katoch, Omika Kaushik, Shikha Kumar, Mysore Sadashiv Yogendra Agrawala, Paban K. Misra, Kshipra Radioprotective property of an aqueous extract from valeriana wallichii |
title | Radioprotective property of an aqueous extract from valeriana wallichii |
title_full | Radioprotective property of an aqueous extract from valeriana wallichii |
title_fullStr | Radioprotective property of an aqueous extract from valeriana wallichii |
title_full_unstemmed | Radioprotective property of an aqueous extract from valeriana wallichii |
title_short | Radioprotective property of an aqueous extract from valeriana wallichii |
title_sort | radioprotective property of an aqueous extract from valeriana wallichii |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523530/ https://www.ncbi.nlm.nih.gov/pubmed/23248568 http://dx.doi.org/10.4103/0975-7406.103272 |
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