A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

[Image: see text] The KRAS oncogene is found in up to 30% of all human tumors. In 2009, RNAi experiments revealed that lowering mRNA levels of a transcript encoding the serine/threonine kinase STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors...

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Detalles Bibliográficos
Autores principales: Weïwer, Michel, Spoonamore, James, Wei, Jingqiang, Guichard, Boris, Ross, Nathan T., Masson, Kristina, Silkworth, Whitney, Dandapani, Sivaraman, Palmer, Michelle, Scherer, Christina A., Stern, Andrew M., Schreiber, Stuart L., Munoz, Benito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523537/
https://www.ncbi.nlm.nih.gov/pubmed/23256033
http://dx.doi.org/10.1021/ml300246r

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523537/
https://www.ncbi.nlm.nih.gov/pubmed/23256033
http://dx.doi.org/10.1021/ml300246r

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