Cargando…

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

[Image: see text] The KRAS oncogene is found in up to 30% of all human tumors. In 2009, RNAi experiments revealed that lowering mRNA levels of a transcript encoding the serine/threonine kinase STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weïwer, Michel, Spoonamore, James, Wei, Jingqiang, Guichard, Boris, Ross, Nathan T., Masson, Kristina, Silkworth, Whitney, Dandapani, Sivaraman, Palmer, Michelle, Scherer, Christina A., Stern, Andrew M., Schreiber, Stuart L., Munoz, Benito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2012
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523537/ https://www.ncbi.nlm.nih.gov/pubmed/23256033 http://dx.doi.org/10.1021/ml300246r

Ejemplares similares

Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33
por: Azoitei, Ninel, et al.
Publicado: (2012)

Rhodium-catalyzed selenylation and sulfenylation of quinoxalinones ‘on water’
por: Lalji, Ram Sunil Kumar, et al.
Publicado: (2023)

Graphene oxide-catalyzed trifluoromethylation of alkynes with quinoxalinones and Langlois' reagent
por: Li, Hong, et al.
Publicado: (2021)

Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations
por: Baumann, Marcus, et al.
Publicado: (2014)

Enantioselective, Visible Light Mediated Aza Paternò–Büchi Reactions of Quinoxalinones
por: Li, Xinyao, et al.
Publicado: (2020)

Discovery of JAK2/3 Inhibitors from Quinoxalinone-Containing Compounds
por: Sanachai, Kamonpan, et al.
Publicado: (2022)

New quinoxalinone inhibitors targeting secreted phospholipase A2 and α-glucosidase
por: Alasmary, Fatmah A. S., et al.
Publicado: (2017)

Correlation between STK33 and the pathology and prognosis of lung cancer
por: Lu, Yi, et al.
Publicado: (2017)

STK33 promotes hepatocellular carcinoma through binding to c-Myc
por: Yang, Tian, et al.
Publicado: (2016)

STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis
por: Huang, Lingyan, et al.
Publicado: (2015)

Iron(III)-Mediated Rapid Radical-Type Three-Component Deuteration of Quinoxalinones With Olefins and NaBD(4)
por: Li, Wanmei, et al.
Publicado: (2020)

Defeat mutant KRAS with synthetic lethality
por: Pang, Xiufeng, et al.
Publicado: (2016)

The Serine/threonine kinase Stk33 exhibits autophosphorylation and phosphorylates the intermediate filament protein Vimentin
por: Brauksiepe, Bastienne, et al.
Publicado: (2008)

A case of synchronous mucinous metaplasia and neoplasia of the female genital tract without an STK11 or KRAS mutation()
por: Nagahama, Kiyotaka, et al.
Publicado: (2013)

STK33/ERK2 signal pathway contribute the tumorigenesis of colorectal cancer HCT15 cells
por: Zhang, Shengjun, et al.
Publicado: (2019)

A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
por: Bery, Nicolas, et al.
Publicado: (2020)

STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis
por: Yu, Weiling, et al.
Publicado: (2023)

Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma
por: Schabath, Matthew B., et al.
Publicado: (2015)

Molecular Signatures of KRAS-Mutated Lung Adenocarcinoma: Analysis of Concomitant EGFR, ALK, STK11, and PD-L1 Status
por: Hsu, Jim, et al.
Publicado: (2022)

A combination therapy for KRAS-mutant lung cancer by targeting synthetic lethal partners of mutant KRAS
por: Pang, Xiufeng, et al.
Publicado: (2016)

The STK33-Linked SNP rs4929949 Is Associated with Obesity and BMI in Two Independent Cohorts of Swedish and Greek Children
por: Rask-Andersen, Mathias, et al.
Publicado: (2013)

Deletions of N33, STK11 and TP53 Are Involved in the Development of Lymph Node Metastasis in Larynx and Pharynx Carcinomas
por: Guervós, Marta Alonso, et al.
Publicado: (2007)

HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage
por: Xie, Yajun, et al.
Publicado: (2019)

STK system acceptance tests
por: Grau, X F
Publicado: (1997)

STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines
por: Grant, Trevor J., et al.
Publicado: (2017)

A Critical Review of the Prognostic and Predictive Implications of KRAS and STK11 Mutations and Co-Mutations in Metastatic Non-Small Lung Cancer
por: Manolakos, Peter, et al.
Publicado: (2023)

Concurrent Mutations in STK11 and KEAP1 Cause Treatment Resistance in KRAS Wild-type Non-small-cell Lung Cancer
por: Sumii, Masahiko, et al.
Publicado: (2023)

CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours
por: Costa-Cabral, Sara, et al.
Publicado: (2016)

Synthetic lethality in KRas-driven cancer cells created by glutamine deprivation
por: Mukhopadhyay, Suman, et al.
Publicado: (2015)

STK33 alleviates gentamicin‐induced ototoxicity in cochlear hair cells and House Ear Institute‐Organ of Corti 1 cells
por: Zhou, Meijuan, et al.
Publicado: (2018)

Primary Resistance to Immune Checkpoint Blockade in an STK11/TP53/KRAS-Mutant Lung Adenocarcinoma with High PD-L1 Expression
por: Kwack, Won Gun, et al.
Publicado: (2020)

Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report
por: Wang, Ru, et al.
Publicado: (2023)

High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling
por: Hartland, Kate, et al.
Publicado: (2015)

Quinoxalinones as A Novel Inhibitor Scaffold for EGFR (L858R/T790M/C797S) Tyrosine Kinase: Molecular Docking, Biological Evaluations, and Computational Insights
por: Suriya, Utid, et al.
Publicado: (2022)

STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1α/VEGF signaling pathway
por: Liu, Yang, et al.
Publicado: (2017)

Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours
por: Costa-Cabral, Sara, et al.
Publicado: (2016)

Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours
por: Costa-Cabral, Sara, et al.
Publicado: (2017)

The novel compound STK405759 is a microtubule-targeting agent with potent and selective cytotoxicity against multiple myeloma in vitro and in vivo
por: Rozic, Gabriela, et al.
Publicado: (2016)

Complete Annotated Genome Sequence of the Salmonella enterica Serovar Typhimurium LT7 Strain STK003, Historically Used in Gene Transfer Studies
por: Zaworski, Julie, et al.
Publicado: (2021)

Are KRAS/BRAF Mutations Potent Prognostic and/or Predictive Biomarkers in Colorectal Cancers?
por: Yokota, Tomoya
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4vlggqm4pp2uv7p8m2ab8arcka