The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 and Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells

[Image: see text] The proprotein convertases (PCs) play an important role in protein precursor activation through processing at paired basic residues. However, significant substrate cleavage redundancy has been reported between PCs. The question remains whether specific PC inhibitors can be designed...

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Detalles Bibliográficos
Autores principales: Levesque, Christine, Fugère, Martin, Kwiatkowska, Anna, Couture, Frédéric, Desjardins, Roxane, Routhier, Sophie, Moussette, Philippe, Prahl, Adam, Lammek, Bernard, Appel, Jon R., Houghten, Richard A., D’Anjou, François, Dory, Yves L., Neugebauer, Witold, Day, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523546/
https://www.ncbi.nlm.nih.gov/pubmed/23126600
http://dx.doi.org/10.1021/jm3011178

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