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Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis
Asymmetric cell division is a developmental process utilized by several organisms. On the most basic level, an asymmetric division produces two daughter cells, each possessing a different identity or fate. Drosophila melanogaster progenitor cells, referred to as neuroblasts, undergo asymmetric divis...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524031/ https://www.ncbi.nlm.nih.gov/pubmed/23151376 http://dx.doi.org/10.1186/2045-3701-2-38 |
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author | Kelsom, Corey Lu, Wange |
author_facet | Kelsom, Corey Lu, Wange |
author_sort | Kelsom, Corey |
collection | PubMed |
description | Asymmetric cell division is a developmental process utilized by several organisms. On the most basic level, an asymmetric division produces two daughter cells, each possessing a different identity or fate. Drosophila melanogaster progenitor cells, referred to as neuroblasts, undergo asymmetric division to produce a daughter neuroblast and another cell known as a ganglion mother cell (GMC). There are several features of asymmetric division in Drosophila that make it a very complex process, and these aspects will be discussed at length. The cell fate determinants that play a role in specifying daughter cell fate, as well as the mechanisms behind setting up cortical polarity within neuroblasts, have proved to be essential to ensuring that neurogenesis occurs properly. The role that mitotic spindle orientation plays in coordinating asymmetric division, as well as how cell cycle regulators influence asymmetric division machinery, will also be addressed. Most significantly, malfunctions during asymmetric cell division have shown to be causally linked with neoplastic growth and tumor formation. Therefore, it is imperative that the developmental repercussions as a result of asymmetric cell division gone awry be understood. |
format | Online Article Text |
id | pubmed-3524031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35240312012-12-18 Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis Kelsom, Corey Lu, Wange Cell Biosci Review Asymmetric cell division is a developmental process utilized by several organisms. On the most basic level, an asymmetric division produces two daughter cells, each possessing a different identity or fate. Drosophila melanogaster progenitor cells, referred to as neuroblasts, undergo asymmetric division to produce a daughter neuroblast and another cell known as a ganglion mother cell (GMC). There are several features of asymmetric division in Drosophila that make it a very complex process, and these aspects will be discussed at length. The cell fate determinants that play a role in specifying daughter cell fate, as well as the mechanisms behind setting up cortical polarity within neuroblasts, have proved to be essential to ensuring that neurogenesis occurs properly. The role that mitotic spindle orientation plays in coordinating asymmetric division, as well as how cell cycle regulators influence asymmetric division machinery, will also be addressed. Most significantly, malfunctions during asymmetric cell division have shown to be causally linked with neoplastic growth and tumor formation. Therefore, it is imperative that the developmental repercussions as a result of asymmetric cell division gone awry be understood. BioMed Central 2012-11-14 /pmc/articles/PMC3524031/ /pubmed/23151376 http://dx.doi.org/10.1186/2045-3701-2-38 Text en Copyright ©2012 Kelsom and Lu; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kelsom, Corey Lu, Wange Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis |
title | Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis |
title_full | Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis |
title_fullStr | Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis |
title_full_unstemmed | Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis |
title_short | Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis |
title_sort | uncovering the link between malfunctions in drosophila neuroblast asymmetric cell division and tumorigenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524031/ https://www.ncbi.nlm.nih.gov/pubmed/23151376 http://dx.doi.org/10.1186/2045-3701-2-38 |
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