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Age-related Epstein-Barr virus-positive cutaneous ulcer arising after a self-limited subcutaneous abscess: a case report

INTRODUCTION: Epstein-Barr virus-positive mucocutaneous ulcer is a newly recognized clinicopathologic entity in the spectrum of Epstein-Barr virus-positive lymphoproliferative disorders. This entity is characterized by a self-limited, indolent course. CASE PRESENTATION: We report the case of a 74-ye...

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Autores principales: Sadiku, Shemsedin, Kurshumliu, Fisnik, Krasniqi, Xhevdet, Brovina, Ahmet, Kryeziu, Emrush, Rrudhani, Ibrahim, Meqa, Kastriot, Gashi-Luci, Lumturije, Merz, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524032/
https://www.ncbi.nlm.nih.gov/pubmed/22967962
http://dx.doi.org/10.1186/1752-1947-6-288
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author Sadiku, Shemsedin
Kurshumliu, Fisnik
Krasniqi, Xhevdet
Brovina, Ahmet
Kryeziu, Emrush
Rrudhani, Ibrahim
Meqa, Kastriot
Gashi-Luci, Lumturije
Merz, Hartmut
author_facet Sadiku, Shemsedin
Kurshumliu, Fisnik
Krasniqi, Xhevdet
Brovina, Ahmet
Kryeziu, Emrush
Rrudhani, Ibrahim
Meqa, Kastriot
Gashi-Luci, Lumturije
Merz, Hartmut
author_sort Sadiku, Shemsedin
collection PubMed
description INTRODUCTION: Epstein-Barr virus-positive mucocutaneous ulcer is a newly recognized clinicopathologic entity in the spectrum of Epstein-Barr virus-positive lymphoproliferative disorders. This entity is characterized by a self-limited, indolent course. CASE PRESENTATION: We report the case of a 74-year-old, type 2 diabetic man who presented with an ulceroinfiltrative skin lesion on the left side of his neck. Histological examination showed that the lesion consisted of large atypical cells, some with Hodgkin-Reed-Sternberg-like morphology, in the midst of reactive lymphocytes, plasma cells, eosinophils and histiocytes. The atypical cells were partially positive for CD45, CD20, CD79a, CD30, B-cell lymphoma 2 and latent membrane protein 1 (CS.1-4), and negative for CD15, B-cell lymphoma 6 and CD10. In situ hybridization for Epstein-Barr virus-encoded ribonucleic acid was positive. Two years before, the patient had been diagnosed with a self-limited subcutaneous abscess in the same anatomic area that healed after antibiotic therapy. CONCLUSION: Older patients with positive Epstein-Barr virus serology may develop B-cell lymphoproliferations due to age-related immune suppression. Epstein-Barr virus-encoded ribonucleic acid testing and clonality analysis, eventually complemented with close clinical follow-up, should be performed for suspicious inflammatory lesions in older patients.
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spelling pubmed-35240322012-12-18 Age-related Epstein-Barr virus-positive cutaneous ulcer arising after a self-limited subcutaneous abscess: a case report Sadiku, Shemsedin Kurshumliu, Fisnik Krasniqi, Xhevdet Brovina, Ahmet Kryeziu, Emrush Rrudhani, Ibrahim Meqa, Kastriot Gashi-Luci, Lumturije Merz, Hartmut J Med Case Rep Case Report INTRODUCTION: Epstein-Barr virus-positive mucocutaneous ulcer is a newly recognized clinicopathologic entity in the spectrum of Epstein-Barr virus-positive lymphoproliferative disorders. This entity is characterized by a self-limited, indolent course. CASE PRESENTATION: We report the case of a 74-year-old, type 2 diabetic man who presented with an ulceroinfiltrative skin lesion on the left side of his neck. Histological examination showed that the lesion consisted of large atypical cells, some with Hodgkin-Reed-Sternberg-like morphology, in the midst of reactive lymphocytes, plasma cells, eosinophils and histiocytes. The atypical cells were partially positive for CD45, CD20, CD79a, CD30, B-cell lymphoma 2 and latent membrane protein 1 (CS.1-4), and negative for CD15, B-cell lymphoma 6 and CD10. In situ hybridization for Epstein-Barr virus-encoded ribonucleic acid was positive. Two years before, the patient had been diagnosed with a self-limited subcutaneous abscess in the same anatomic area that healed after antibiotic therapy. CONCLUSION: Older patients with positive Epstein-Barr virus serology may develop B-cell lymphoproliferations due to age-related immune suppression. Epstein-Barr virus-encoded ribonucleic acid testing and clonality analysis, eventually complemented with close clinical follow-up, should be performed for suspicious inflammatory lesions in older patients. BioMed Central 2012-09-11 /pmc/articles/PMC3524032/ /pubmed/22967962 http://dx.doi.org/10.1186/1752-1947-6-288 Text en Copyright ©2012 Sadiku et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sadiku, Shemsedin
Kurshumliu, Fisnik
Krasniqi, Xhevdet
Brovina, Ahmet
Kryeziu, Emrush
Rrudhani, Ibrahim
Meqa, Kastriot
Gashi-Luci, Lumturije
Merz, Hartmut
Age-related Epstein-Barr virus-positive cutaneous ulcer arising after a self-limited subcutaneous abscess: a case report
title Age-related Epstein-Barr virus-positive cutaneous ulcer arising after a self-limited subcutaneous abscess: a case report
title_full Age-related Epstein-Barr virus-positive cutaneous ulcer arising after a self-limited subcutaneous abscess: a case report
title_fullStr Age-related Epstein-Barr virus-positive cutaneous ulcer arising after a self-limited subcutaneous abscess: a case report
title_full_unstemmed Age-related Epstein-Barr virus-positive cutaneous ulcer arising after a self-limited subcutaneous abscess: a case report
title_short Age-related Epstein-Barr virus-positive cutaneous ulcer arising after a self-limited subcutaneous abscess: a case report
title_sort age-related epstein-barr virus-positive cutaneous ulcer arising after a self-limited subcutaneous abscess: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524032/
https://www.ncbi.nlm.nih.gov/pubmed/22967962
http://dx.doi.org/10.1186/1752-1947-6-288
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