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8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Oxidative damage to DNA is mainly repaired via base excision repair, a pathway that is catalyzed by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1). While OGG1 has been implicated in maintaining genomic integrity and preventing tumorigenesis, we report a novel role for OGG1 in altering...

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Detalles Bibliográficos
Autores principales:	Sampath, Harini, Vartanian, Vladimir, Rollins, M. Rick, Sakumi, Kunihiko, Nakabeppu, Yusaku, Lloyd, R. Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524114/ https://www.ncbi.nlm.nih.gov/pubmed/23284747 http://dx.doi.org/10.1371/journal.pone.0051697

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