Cargando…

Using Family-Based Imputation in Genome-Wide Association Studies with Large Complex Pedigrees: The Framingham Heart Study

Imputation has been widely used in genome-wide association studies (GWAS) to infer genotypes of un-genotyped variants based on the linkage disequilibrium in external reference panels such as the HapMap and 1000 Genomes. However, imputation has only rarely been performed based on family relationships...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Ming-Huei, Huang, Jie, Chen, Wei-Min, Larson, Martin G., Fox, Caroline S., Vasan, Ramachandran S., Seshadri, Sudha, O’Donnell, Christopher J., Yang, Qiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524237/ https://www.ncbi.nlm.nih.gov/pubmed/23284720 http://dx.doi.org/10.1371/journal.pone.0051589

Ejemplares similares

Patterns of Abdominal Fat Distribution: The Framingham Heart Study
por: Pou, Karla M., et al.
Publicado: (2009)

Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
por: Larson, Martin G, et al.
Publicado: (2007)

ADP Platelet Hyperreactivity Predicts Cardiovascular Disease in the FHS (Framingham Heart Study)
por: Puurunen, Marja K., et al.
Publicado: (2018)

Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study
por: Aparicio, Hugo J., et al.
Publicado: (2017)

Pedigree and genotype errors in the Framingham Heart Study
por: Brush, Gerry, et al.
Publicado: (2003)

Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study
por: Cheng, Susan, et al.
Publicado: (2010)

Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study
por: Romero, José R., et al.
Publicado: (2016)

Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project
por: Fox, Caroline S, et al.
Publicado: (2007)

Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
por: Vasan, Ramachandran S, et al.
Publicado: (2007)

Association of Lifestyle Factors With Abdominal Subcutaneous and Visceral Adiposity: The Framingham Heart Study
por: Molenaar, Esther A., et al.
Publicado: (2009)

Digital Peripheral Arterial Tonometry and Cardiovascular Disease Events: The Framingham Heart Study
por: Cooper, Leroy L., et al.
Publicado: (2021)

Cross-Sectional Associations Bet ween Abdominal and Thoracic Adipose Tissue Compartments and Adiponectin and Resistin in the Framingham Heart Study
por: Jain, Shilpa H., et al.
Publicado: (2009)

Association of Metabolic Dysregulation With Volumetric Brain Magnetic Resonance Imaging and Cognitive Markers of Subclinical Brain Aging in Middle-Aged Adults: The Framingham Offspring Study
por: Tan, Zaldy S., et al.
Publicado: (2011)

Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the framingham heart study
por: O'Seaghdha, Conall M, et al.
Publicado: (2012)

Self-Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study
por: Spartano, Nicole L., et al.
Publicado: (2019)

Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study
por: Dallmeier, Dhayana, et al.
Publicado: (2012)

Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
por: Newton-Cheh, Christopher, et al.
Publicado: (2007)

Relations of postural change in blood pressure with hypertension-mediated organ damage in middle-aged adults of the Framingham heart study: A cross-sectional study
por: Cooper, Leroy L., et al.
Publicado: (2022)

Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
por: Yang, Qiong, et al.
Publicado: (2007)

Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
por: Levy, Daniel, et al.
Publicado: (2007)

Comparison and assessment of family- and population-based genotype imputation methods in large pedigrees
por: Ullah, Ehsan, et al.
Publicado: (2019)

The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
por: Cupples, L Adrienne, et al.
Publicado: (2007)

Neck Circumference and the Development of Cardiovascular Disease Risk Factors in the Framingham Heart Study
por: Preis, Sarah Rosner, et al.
Publicado: (2013)

Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study
por: Spartano, Nicole L., et al.
Publicado: (2019)

Red Blood Cell DHA Is Inversely Associated with Risk of Incident Alzheimer’s Disease and All-Cause Dementia: Framingham Offspring Study
por: Sala-Vila, Aleix, et al.
Publicado: (2022)

Identifying Blood Biomarkers for Dementia Using Machine Learning Methods in the Framingham Heart Study
por: Lin, Honghuang, et al.
Publicado: (2022)

Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
por: Kottgen, Anna, et al.
Publicado: (2008)

Whole genome sequence analyses of brain imaging measures in the Framingham Study
por: Sarnowski, Chloé, et al.
Publicado: (2018)

Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study
por: McGrath, Emer R., et al.
Publicado: (2019)

Genome-wide association with select biomarker traits in the Framingham Heart Study
por: Benjamin, Emelia J, et al.
Publicado: (2007)

Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study
por: Spartano, Nicole L., et al.
Publicado: (2019)

Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes
por: Ho, Jennifer E., et al.
Publicado: (2016)

Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
por: O'Donnell, Christopher J, et al.
Publicado: (2007)

Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study
por: Foster, Meredith C, et al.
Publicado: (2011)

Long‐term Cardiovascular Risks Associated With an Elevated Heart Rate: The Framingham Heart Study
por: Ho, Jennifer E., et al.
Publicado: (2014)

Multi-system trajectories and the incidence of heart failure in the Framingham Offspring Study
por: Guardino, Cara E., et al.
Publicado: (2022)

Periaortic Adipose Tissue and Aortic Dimensions in the Framingham Heart Study
por: Thanassoulis, George, et al.
Publicado: (2012)

Bone Mineral Density Measurements and Association With Brain Structure and Cognitive Function: The Framingham Offspring Cohort
por: Stefanidou, Maria, et al.
Publicado: (2021)

Cross‐Sectional Associations of Computed Tomography (CT)‐Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study
por: Lee, Jane J., et al.
Publicado: (2016)

Windkessel Measures Derived From Pressure Waveforms Only: The Framingham Heart Study
por: Behnam, Vira, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8mn001200dr00ggtvc2gqf93oo