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Hypertrophic Chondrocytes Have a Limited Capacity to Cope with Increases in Endoplasmic Reticulum Stress without Triggering the Unfolded Protein Response

Mutations causing metaphyseal chondrodysplasia type Schmid (MCDS) (e.g., Col10a1p.N617K) induce the pathology by a mechanism involving increased endoplasmic reticulum (ER) stress triggering an unfolded protein response (UPR) in hypertrophic chondrocytes (Rajpar et al. 2009). Here we correlate the ex...

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Detalles Bibliográficos
Autores principales: Kung, Louise H. W., Rajpar, M. Helen, Briggs, Michael D., Boot-Handford, Raymond P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524565/
https://www.ncbi.nlm.nih.gov/pubmed/22859705
http://dx.doi.org/10.1369/0022155412458436

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