Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

Doxorubicin is used extensively for chemotherapy of diverse types of cancer, yet the mechanism through which it inhibits proliferation of cancer cells remains unclear. Here we report that doxorubicin stimulates de novo synthesis of ceramide, which in turn activates CREB3L1, a transcription factor sy...

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Detalles Bibliográficos
Autores principales: Denard, Bray, Lee, Ching, Ye, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2012
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524649/
https://www.ncbi.nlm.nih.gov/pubmed/23256041
http://dx.doi.org/10.7554/eLife.00090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524649/
https://www.ncbi.nlm.nih.gov/pubmed/23256041
http://dx.doi.org/10.7554/eLife.00090

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