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Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: Clinical significance of measurement for nitrate/nitrite

BACKGROUND: A visceral fat area of more than 100 cm(2) as measured by computed tomography (CT) at the umbilical level has been included as a criterion for obesity in all the proposed criteria for metabolic syndrome. However, CT cannot be used frequently because of radiation exposure. We evaluated th...

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Autores principales: Fujita, Koji, Wada, Koichiro, Nozaki, Yuichi, Yoneda, Masato, Endo, Hiroki, Takahashi, Hirokazu, Kirikoshi, Hiroyuki, Inamori, Masahiko, Kobayashi, Noritoshi, Kubota, Kensuke, Saito, Satoru, Nakajima, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524723/
https://www.ncbi.nlm.nih.gov/pubmed/21358598
http://dx.doi.org/10.12659/MSM.881445
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author Fujita, Koji
Wada, Koichiro
Nozaki, Yuichi
Yoneda, Masato
Endo, Hiroki
Takahashi, Hirokazu
Kirikoshi, Hiroyuki
Inamori, Masahiko
Kobayashi, Noritoshi
Kubota, Kensuke
Saito, Satoru
Nakajima, Atsushi
author_facet Fujita, Koji
Wada, Koichiro
Nozaki, Yuichi
Yoneda, Masato
Endo, Hiroki
Takahashi, Hirokazu
Kirikoshi, Hiroyuki
Inamori, Masahiko
Kobayashi, Noritoshi
Kubota, Kensuke
Saito, Satoru
Nakajima, Atsushi
author_sort Fujita, Koji
collection PubMed
description BACKGROUND: A visceral fat area of more than 100 cm(2) as measured by computed tomography (CT) at the umbilical level has been included as a criterion for obesity in all the proposed criteria for metabolic syndrome. However, CT cannot be used frequently because of radiation exposure. We evaluated the usefulness of measurement of the serum levels of nitric oxide (NO), instead of CT and the waist circumference, as a marker of abdominal visceral fat accumulation. MATERIAL/METHODS: The study was carried out in 80 subjects. The serum levels of NO metabolites (nitrate/nitrite) were measured using the Griess reagent. RESULTS: Simple and multiple regression analysis revealed that the serum levels of NO metabolites showed the greatest degree of correlation with the visceral fat area (r=0.743, p<0.0001), and corresponded to a visceral fat area of 100 cm(2), as determined using the ROC curve, was 21.0 μmol/ml (sensitivity 88%, specificity 82%); this method was more sensitive than the waist circumference for evaluation of the visceral fat accumulation. CONCLUSIONS: Measurement of the serum levels of NO metabolites may be a simple, safe, convenient and reliable method for the evaluation of visceral fat accumulation in clinical diagnostic screening.
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spelling pubmed-35247232013-04-24 Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: Clinical significance of measurement for nitrate/nitrite Fujita, Koji Wada, Koichiro Nozaki, Yuichi Yoneda, Masato Endo, Hiroki Takahashi, Hirokazu Kirikoshi, Hiroyuki Inamori, Masahiko Kobayashi, Noritoshi Kubota, Kensuke Saito, Satoru Nakajima, Atsushi Med Sci Monit Clinical Research BACKGROUND: A visceral fat area of more than 100 cm(2) as measured by computed tomography (CT) at the umbilical level has been included as a criterion for obesity in all the proposed criteria for metabolic syndrome. However, CT cannot be used frequently because of radiation exposure. We evaluated the usefulness of measurement of the serum levels of nitric oxide (NO), instead of CT and the waist circumference, as a marker of abdominal visceral fat accumulation. MATERIAL/METHODS: The study was carried out in 80 subjects. The serum levels of NO metabolites (nitrate/nitrite) were measured using the Griess reagent. RESULTS: Simple and multiple regression analysis revealed that the serum levels of NO metabolites showed the greatest degree of correlation with the visceral fat area (r=0.743, p<0.0001), and corresponded to a visceral fat area of 100 cm(2), as determined using the ROC curve, was 21.0 μmol/ml (sensitivity 88%, specificity 82%); this method was more sensitive than the waist circumference for evaluation of the visceral fat accumulation. CONCLUSIONS: Measurement of the serum levels of NO metabolites may be a simple, safe, convenient and reliable method for the evaluation of visceral fat accumulation in clinical diagnostic screening. International Scientific Literature, Inc. 2011-03-01 /pmc/articles/PMC3524723/ /pubmed/21358598 http://dx.doi.org/10.12659/MSM.881445 Text en © Med Sci Monit, 2011 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
spellingShingle Clinical Research
Fujita, Koji
Wada, Koichiro
Nozaki, Yuichi
Yoneda, Masato
Endo, Hiroki
Takahashi, Hirokazu
Kirikoshi, Hiroyuki
Inamori, Masahiko
Kobayashi, Noritoshi
Kubota, Kensuke
Saito, Satoru
Nakajima, Atsushi
Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: Clinical significance of measurement for nitrate/nitrite
title Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: Clinical significance of measurement for nitrate/nitrite
title_full Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: Clinical significance of measurement for nitrate/nitrite
title_fullStr Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: Clinical significance of measurement for nitrate/nitrite
title_full_unstemmed Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: Clinical significance of measurement for nitrate/nitrite
title_short Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: Clinical significance of measurement for nitrate/nitrite
title_sort serum nitric oxide metabolite as a biomarker of visceral fat accumulation: clinical significance of measurement for nitrate/nitrite
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524723/
https://www.ncbi.nlm.nih.gov/pubmed/21358598
http://dx.doi.org/10.12659/MSM.881445
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