Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease

BACKGROUND: One of the best-characterized causative factors of Alzheimer’s disease (AD) is the generation of amyloid-β peptide (Aβ). AD subjects are at high risk of epileptic seizures accompanied by aberrant neuronal excitability, which in itself enhances Aβ generation. However, the molecular linkag...

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Detalles Bibliográficos
Autores principales: Saito, Yuhki, Inoue, Tsuyoshi, Zhu, Gang, Kimura, Naoki, Okada, Motohiro, Nishimura, Masaki, Kimura, Nobuyuki, Murayama, Shigeo, Kaneko, Sunao, Shigemoto, Ryuichi, Imoto, Keiji, Suzuki, Toshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524764/
https://www.ncbi.nlm.nih.gov/pubmed/23034178
http://dx.doi.org/10.1186/1750-1326-7-50

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