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DB Dehydrogenase: an online integrated structural database on enzyme dehydrogenase

Dehydrogenase enzymes are almost inevitable for metabolic processes. Shortage or malfunctioning of dehydrogenases often leads to several acute diseases like cancers, retinal diseases, diabetes mellitus, Alzheimer, hepatitis B & C etc. With advancement in modern-day research, huge amount of seque...

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Detalles Bibliográficos
Autores principales: Nandy, Suman Kumar, Bhuyan, Rajabrata, Seal, Alpana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524946/
https://www.ncbi.nlm.nih.gov/pubmed/23275696
http://dx.doi.org/10.6026/97320630081000
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author Nandy, Suman Kumar
Bhuyan, Rajabrata
Seal, Alpana
author_facet Nandy, Suman Kumar
Bhuyan, Rajabrata
Seal, Alpana
author_sort Nandy, Suman Kumar
collection PubMed
description Dehydrogenase enzymes are almost inevitable for metabolic processes. Shortage or malfunctioning of dehydrogenases often leads to several acute diseases like cancers, retinal diseases, diabetes mellitus, Alzheimer, hepatitis B & C etc. With advancement in modern-day research, huge amount of sequential, structural and functional data are generated everyday and widens the gap between structural attributes and its functional understanding. DB Dehydrogenase is an effort to relate the functionalities of dehydrogenase with its structures. It is a completely web-based structural database, covering almost all dehydrogenases [~150 enzyme classes, ~1200 entries from ~160 organisms] whose structures are known. It is created by extracting and integrating various online resources to provide the true and reliable data and implemented by MySQL relational database through user friendly web interfaces using CGI Perl. Flexible search options are there for data extraction and exploration. To summarize, sequence, structure, function of all dehydrogenases in one place along with the necessary option of cross-referencing; this database will be utile for researchers to carry out further work in this field. AVAILABILITY: The database is available for free at http://www.bifku.in/DBD/
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spelling pubmed-35249462012-12-28 DB Dehydrogenase: an online integrated structural database on enzyme dehydrogenase Nandy, Suman Kumar Bhuyan, Rajabrata Seal, Alpana Bioinformation Database Dehydrogenase enzymes are almost inevitable for metabolic processes. Shortage or malfunctioning of dehydrogenases often leads to several acute diseases like cancers, retinal diseases, diabetes mellitus, Alzheimer, hepatitis B & C etc. With advancement in modern-day research, huge amount of sequential, structural and functional data are generated everyday and widens the gap between structural attributes and its functional understanding. DB Dehydrogenase is an effort to relate the functionalities of dehydrogenase with its structures. It is a completely web-based structural database, covering almost all dehydrogenases [~150 enzyme classes, ~1200 entries from ~160 organisms] whose structures are known. It is created by extracting and integrating various online resources to provide the true and reliable data and implemented by MySQL relational database through user friendly web interfaces using CGI Perl. Flexible search options are there for data extraction and exploration. To summarize, sequence, structure, function of all dehydrogenases in one place along with the necessary option of cross-referencing; this database will be utile for researchers to carry out further work in this field. AVAILABILITY: The database is available for free at http://www.bifku.in/DBD/ Biomedical Informatics 2012-10-13 /pmc/articles/PMC3524946/ /pubmed/23275696 http://dx.doi.org/10.6026/97320630081000 Text en © 2012 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Database
Nandy, Suman Kumar
Bhuyan, Rajabrata
Seal, Alpana
DB Dehydrogenase: an online integrated structural database on enzyme dehydrogenase
title DB Dehydrogenase: an online integrated structural database on enzyme dehydrogenase
title_full DB Dehydrogenase: an online integrated structural database on enzyme dehydrogenase
title_fullStr DB Dehydrogenase: an online integrated structural database on enzyme dehydrogenase
title_full_unstemmed DB Dehydrogenase: an online integrated structural database on enzyme dehydrogenase
title_short DB Dehydrogenase: an online integrated structural database on enzyme dehydrogenase
title_sort db dehydrogenase: an online integrated structural database on enzyme dehydrogenase
topic Database
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524946/
https://www.ncbi.nlm.nih.gov/pubmed/23275696
http://dx.doi.org/10.6026/97320630081000
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