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Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps
Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genom...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525001/ https://www.ncbi.nlm.nih.gov/pubmed/15601531 http://dx.doi.org/10.1186/1479-7364-1-1-30 |
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author | Murphy, William J Bourque, Guillaume Tesler, Glenn Pevzner, Pavel O'Brien, Stephen J |
author_facet | Murphy, William J Bourque, Guillaume Tesler, Glenn Pevzner, Pavel O'Brien, Stephen J |
author_sort | Murphy, William J |
collection | PubMed |
description | Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genome Rearrangement (MGR) algorithm is applied to human, mouse, cat and cattle comparative maps (with 311-470 shared markers) to impute the ancestral mammalian genome. Reconstructed ancestors consist of 70-100 conserved segments shared across the genomes that have been exchanged by rearrangement events along the ordinal lineages leading to modern species genomes. Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes. |
format | Online Article Text |
id | pubmed-3525001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35250012012-12-19 Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps Murphy, William J Bourque, Guillaume Tesler, Glenn Pevzner, Pavel O'Brien, Stephen J Hum Genomics Primary Research Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genome Rearrangement (MGR) algorithm is applied to human, mouse, cat and cattle comparative maps (with 311-470 shared markers) to impute the ancestral mammalian genome. Reconstructed ancestors consist of 70-100 conserved segments shared across the genomes that have been exchanged by rearrangement events along the ordinal lineages leading to modern species genomes. Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes. BioMed Central 2003-11-01 /pmc/articles/PMC3525001/ /pubmed/15601531 http://dx.doi.org/10.1186/1479-7364-1-1-30 Text en Copyright ©2003 Henry Stewart Publications |
spellingShingle | Primary Research Murphy, William J Bourque, Guillaume Tesler, Glenn Pevzner, Pavel O'Brien, Stephen J Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title | Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title_full | Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title_fullStr | Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title_full_unstemmed | Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title_short | Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title_sort | reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
topic | Primary Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525001/ https://www.ncbi.nlm.nih.gov/pubmed/15601531 http://dx.doi.org/10.1186/1479-7364-1-1-30 |
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