Transimination of Quinone Imines: A Mechanism for Embedding Exogenous Redox Activity into the Nucleosome

[Image: see text] Aminophenols can redox cycle through the corresponding quinone imines to generate ROS. The electrophilic quinone imine intermediate can react with protein thiols as a mechanism of immobilization in vivo. Here, we describe the previously unkown transimination of a quinone imine by l...

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Detalles Bibliográficos
Autores principales: Ye, Wenjie, Seneviratne, Uthpala I., Chao, Ming-Wei, Ravindra, Kodihalli C., Wogan, Gerald N., Tannenbaum, Steven R., Skipper, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525013/
https://www.ncbi.nlm.nih.gov/pubmed/23194336
http://dx.doi.org/10.1021/tx3004517

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