Formation of ion pairing as an alternative to improve encapsulation and anticancer activity of all-trans retinoic acid loaded in solid lipid nanoparticles

This work aims to develop solid lipid nanoparticles (SLNs) loaded with retinoic acid (RA) to evaluate the influence of two lipophilic amines, stearylamine (SA) and benethamine (BA), and one hydrophilic, triethylamine (TA), on drug-encapsulation efficiency (EE) and cytotoxicity in cancer cell lines....

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Detalles Bibliográficos
Autores principales: Carneiro, Guilherme, Silva, Elton Luiz, Pacheco, Layssa Alves, de Souza-Fagundes, Elaine Maria, Corrêa, Natássia Caroline Resende, de Goes, Alfredo Miranda, de Oliveira, Mônica Cristina, Ferreira, Lucas Antônio Miranda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525049/
https://www.ncbi.nlm.nih.gov/pubmed/23251090
http://dx.doi.org/10.2147/IJN.S38953

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