Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers

Polymorphisms in drug transporter genes and/or drug-metabolising enzyme genes may contribute to inter-individual variability in rosiglitazone pharmacokinetics in humans. We sought to determine the joint effects of polymorphisms in the SLCO1B1 drug transporter gene and the cytochrome P450 (CYP) 2C8-m...

Descripción completa

Detalles Bibliográficos
Autores principales: Aquilante, Christina L, Bushman, Lane R, Knutsen, Shannon D, Burt, Lauren E, Rome, Lucille Capo, Kosmiski, Lisa A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525178/
https://www.ncbi.nlm.nih.gov/pubmed/19129086
http://dx.doi.org/10.1186/1479-7364-3-1-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525178/
https://www.ncbi.nlm.nih.gov/pubmed/19129086
http://dx.doi.org/10.1186/1479-7364-3-1-7

Ejemplares similares