Mitochondrial DNA sequence variation and neurodegeneration

Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Moreover, there is a long history of investigations on mitochondria...

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Detalles Bibliográficos
Autores principales: Mancuso, Michelangelo, Filosto, Massimiliano, Orsucci, Daniele, Siciliano, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525185/
https://www.ncbi.nlm.nih.gov/pubmed/19129091
http://dx.doi.org/10.1186/1479-7364-3-1-71
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author Mancuso, Michelangelo
Filosto, Massimiliano
Orsucci, Daniele
Siciliano, Gabriele
author_facet Mancuso, Michelangelo
Filosto, Massimiliano
Orsucci, Daniele
Siciliano, Gabriele
author_sort Mancuso, Michelangelo
collection PubMed
description Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Moreover, there is a long history of investigations on mitochondria aimed at identifying genetic markers relating to ageing and neurodegenerative diseases. In this review, some of the major neurodegenerative disorders are highlighted and the role of mitochondrial haplogroups in the pathogenetic cascade leading to these diseases is discussed.
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spelling pubmed-35251852012-12-19 Mitochondrial DNA sequence variation and neurodegeneration Mancuso, Michelangelo Filosto, Massimiliano Orsucci, Daniele Siciliano, Gabriele Hum Genomics Review Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Moreover, there is a long history of investigations on mitochondria aimed at identifying genetic markers relating to ageing and neurodegenerative diseases. In this review, some of the major neurodegenerative disorders are highlighted and the role of mitochondrial haplogroups in the pathogenetic cascade leading to these diseases is discussed. BioMed Central 2008-09-01 /pmc/articles/PMC3525185/ /pubmed/19129091 http://dx.doi.org/10.1186/1479-7364-3-1-71 Text en Copyright ©2008 Henry Stewart Publications
spellingShingle Review
Mancuso, Michelangelo
Filosto, Massimiliano
Orsucci, Daniele
Siciliano, Gabriele
Mitochondrial DNA sequence variation and neurodegeneration
title Mitochondrial DNA sequence variation and neurodegeneration
title_full Mitochondrial DNA sequence variation and neurodegeneration
title_fullStr Mitochondrial DNA sequence variation and neurodegeneration
title_full_unstemmed Mitochondrial DNA sequence variation and neurodegeneration
title_short Mitochondrial DNA sequence variation and neurodegeneration
title_sort mitochondrial dna sequence variation and neurodegeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525185/
https://www.ncbi.nlm.nih.gov/pubmed/19129091
http://dx.doi.org/10.1186/1479-7364-3-1-71
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AT filostomassimiliano mitochondrialdnasequencevariationandneurodegeneration
AT orsuccidaniele mitochondrialdnasequencevariationandneurodegeneration
AT sicilianogabriele mitochondrialdnasequencevariationandneurodegeneration

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