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Transient receptor potential (TRP) gene superfamily encoding cation channels
Transient receptor potential (TRP) non-selective cation channels constitute a superfamily, which contains 28 different genes. In mammals, this superfamily is divided into six subfamilies based on differences in amino acid sequence homology between the different gene products. Proteins within a subfa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525231/ https://www.ncbi.nlm.nih.gov/pubmed/21296744 http://dx.doi.org/10.1186/1479-7364-5-2-108 |
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author | Pan, Zan Yang, Hua Reinach, Peter S |
author_facet | Pan, Zan Yang, Hua Reinach, Peter S |
author_sort | Pan, Zan |
collection | PubMed |
description | Transient receptor potential (TRP) non-selective cation channels constitute a superfamily, which contains 28 different genes. In mammals, this superfamily is divided into six subfamilies based on differences in amino acid sequence homology between the different gene products. Proteins within a subfamily aggregate to form heteromeric or homomeric tetrameric configurations. These different groupings have very variable permeability ratios for calcium versus sodium ions. TRP expression is widely distributed in neuronal tissues, as well as a host of other tissues, including epithelial and endothelial cells. They are activated by environmental stresses that include tissue injury, changes in temperature, pH and osmolarity, as well as volatile chemicals, cytokines and plant compounds. Their activation induces, via intracellular calcium signalling, a host of responses, including stimulation of cell proliferation, migration, regulatory volume behaviour and the release of a host of cytokines. Their activation is greatly potentiated by phospholipase C (PLC) activation mediated by coupled GTP-binding proteins and tyrosine receptors. In addition to their importance in maintaining tissue homeostasis, some of these responses may involve various underlying diseases. Given the wealth of literature describing the multiple roles of TRP in physiology in a very wide range of different mammalian tissues, this review limits itself to the literature describing the multiple roles of TRP channels in different ocular tissues. Accordingly, their importance to the corneal, trabecular meshwork, lens, ciliary muscle, retinal, microglial and retinal pigment epithelial physiology and pathology is reviewed. |
format | Online Article Text |
id | pubmed-3525231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35252312012-12-19 Transient receptor potential (TRP) gene superfamily encoding cation channels Pan, Zan Yang, Hua Reinach, Peter S Hum Genomics Genome Update Transient receptor potential (TRP) non-selective cation channels constitute a superfamily, which contains 28 different genes. In mammals, this superfamily is divided into six subfamilies based on differences in amino acid sequence homology between the different gene products. Proteins within a subfamily aggregate to form heteromeric or homomeric tetrameric configurations. These different groupings have very variable permeability ratios for calcium versus sodium ions. TRP expression is widely distributed in neuronal tissues, as well as a host of other tissues, including epithelial and endothelial cells. They are activated by environmental stresses that include tissue injury, changes in temperature, pH and osmolarity, as well as volatile chemicals, cytokines and plant compounds. Their activation induces, via intracellular calcium signalling, a host of responses, including stimulation of cell proliferation, migration, regulatory volume behaviour and the release of a host of cytokines. Their activation is greatly potentiated by phospholipase C (PLC) activation mediated by coupled GTP-binding proteins and tyrosine receptors. In addition to their importance in maintaining tissue homeostasis, some of these responses may involve various underlying diseases. Given the wealth of literature describing the multiple roles of TRP in physiology in a very wide range of different mammalian tissues, this review limits itself to the literature describing the multiple roles of TRP channels in different ocular tissues. Accordingly, their importance to the corneal, trabecular meshwork, lens, ciliary muscle, retinal, microglial and retinal pigment epithelial physiology and pathology is reviewed. BioMed Central 2011-01-01 /pmc/articles/PMC3525231/ /pubmed/21296744 http://dx.doi.org/10.1186/1479-7364-5-2-108 Text en Copyright ©2011 Henry Stewart Publications |
spellingShingle | Genome Update Pan, Zan Yang, Hua Reinach, Peter S Transient receptor potential (TRP) gene superfamily encoding cation channels |
title | Transient receptor potential (TRP) gene superfamily encoding cation channels |
title_full | Transient receptor potential (TRP) gene superfamily encoding cation channels |
title_fullStr | Transient receptor potential (TRP) gene superfamily encoding cation channels |
title_full_unstemmed | Transient receptor potential (TRP) gene superfamily encoding cation channels |
title_short | Transient receptor potential (TRP) gene superfamily encoding cation channels |
title_sort | transient receptor potential (trp) gene superfamily encoding cation channels |
topic | Genome Update |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525231/ https://www.ncbi.nlm.nih.gov/pubmed/21296744 http://dx.doi.org/10.1186/1479-7364-5-2-108 |
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