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In-silico human genomics with GeneCards
Since 1998, the bioinformatics, systems biology, genomics and medical communities have enjoyed a synergistic relationship with the GeneCards database of human genes (http://www.genecards.org). This human gene compendium was created to help to introduce order into the increasing chaos of information...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525253/ https://www.ncbi.nlm.nih.gov/pubmed/22155609 http://dx.doi.org/10.1186/1479-7364-5-6-709 |
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author | Stelzer, Gil Dalah, Irina Stein, Tsippi Iny Satanower, Yigeal Rosen, Naomi Nativ, Noam Oz-Levi, Danit Olender, Tsviya Belinky, Frida Bahir, Iris Krug, Hagit Perco, Paul Mayer, Bernd Kolker, Eugene Safran, Marilyn Lancet, Doron |
author_facet | Stelzer, Gil Dalah, Irina Stein, Tsippi Iny Satanower, Yigeal Rosen, Naomi Nativ, Noam Oz-Levi, Danit Olender, Tsviya Belinky, Frida Bahir, Iris Krug, Hagit Perco, Paul Mayer, Bernd Kolker, Eugene Safran, Marilyn Lancet, Doron |
author_sort | Stelzer, Gil |
collection | PubMed |
description | Since 1998, the bioinformatics, systems biology, genomics and medical communities have enjoyed a synergistic relationship with the GeneCards database of human genes (http://www.genecards.org). This human gene compendium was created to help to introduce order into the increasing chaos of information flow. As a consequence of viewing details and deep links related to specific genes, users have often requested enhanced capabilities, such that, over time, GeneCards has blossomed into a suite of tools (including GeneDecks, GeneALaCart, GeneLoc, GeneNote and GeneAnnot) for a variety of analyses of both single human genes and sets thereof. In this paper, we focus on inhouse and external research activities which have been enabled, enhanced, complemented and, in some cases, motivated by GeneCards. In turn, such interactions have often inspired and propelled improvements in GeneCards. We describe here the evolution and architecture of this project, including examples of synergistic applications in diverse areas such as synthetic lethality in cancer, the annotation of genetic variations in disease, omics integration in a systems biology approach to kidney disease, and bioinformatics tools. |
format | Online Article Text |
id | pubmed-3525253 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35252532012-12-19 In-silico human genomics with GeneCards Stelzer, Gil Dalah, Irina Stein, Tsippi Iny Satanower, Yigeal Rosen, Naomi Nativ, Noam Oz-Levi, Danit Olender, Tsviya Belinky, Frida Bahir, Iris Krug, Hagit Perco, Paul Mayer, Bernd Kolker, Eugene Safran, Marilyn Lancet, Doron Hum Genomics Genome Databases Since 1998, the bioinformatics, systems biology, genomics and medical communities have enjoyed a synergistic relationship with the GeneCards database of human genes (http://www.genecards.org). This human gene compendium was created to help to introduce order into the increasing chaos of information flow. As a consequence of viewing details and deep links related to specific genes, users have often requested enhanced capabilities, such that, over time, GeneCards has blossomed into a suite of tools (including GeneDecks, GeneALaCart, GeneLoc, GeneNote and GeneAnnot) for a variety of analyses of both single human genes and sets thereof. In this paper, we focus on inhouse and external research activities which have been enabled, enhanced, complemented and, in some cases, motivated by GeneCards. In turn, such interactions have often inspired and propelled improvements in GeneCards. We describe here the evolution and architecture of this project, including examples of synergistic applications in diverse areas such as synthetic lethality in cancer, the annotation of genetic variations in disease, omics integration in a systems biology approach to kidney disease, and bioinformatics tools. BioMed Central 2011-10-01 /pmc/articles/PMC3525253/ /pubmed/22155609 http://dx.doi.org/10.1186/1479-7364-5-6-709 Text en Copyright ©2011 Henry Stewart Publications |
spellingShingle | Genome Databases Stelzer, Gil Dalah, Irina Stein, Tsippi Iny Satanower, Yigeal Rosen, Naomi Nativ, Noam Oz-Levi, Danit Olender, Tsviya Belinky, Frida Bahir, Iris Krug, Hagit Perco, Paul Mayer, Bernd Kolker, Eugene Safran, Marilyn Lancet, Doron In-silico human genomics with GeneCards |
title | In-silico human genomics with GeneCards |
title_full | In-silico human genomics with GeneCards |
title_fullStr | In-silico human genomics with GeneCards |
title_full_unstemmed | In-silico human genomics with GeneCards |
title_short | In-silico human genomics with GeneCards |
title_sort | in-silico human genomics with genecards |
topic | Genome Databases |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525253/ https://www.ncbi.nlm.nih.gov/pubmed/22155609 http://dx.doi.org/10.1186/1479-7364-5-6-709 |
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