Cargando…
Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects
Pharmacogenetics enables personalised therapy based on genetic profiling and is increasingly applied in drug discovery. Medicines are developed and used together with pharmacodiagnostic tools to achieve desired drug efficacy and safety margins. Genetic polymorphism of drug-metabolising enzymes such...
Autores principales: | Matimba, Alice, Del-Favero, Jurgen, Van Broeckhoven, Christine, Masimirembwa, Collen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525272/ https://www.ncbi.nlm.nih.gov/pubmed/19164093 http://dx.doi.org/10.1186/1479-7364-3-2-169 |
Ejemplares similares
-
African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug Development
por: Rajman, Iris, et al.
Publicado: (2017) -
Investigating the Contribution of Major Drug-Metabolising Enzymes to Possum-Specific Fertility Control
por: Chand, Ravneel R., et al.
Publicado: (2023) -
Pharmacokinetics of Tamoxifen and Its Major Metabolites and the Effect of the African Ancestry Specific CYP2D6*17 Variant on the Formation of the Active Metabolite, Endoxifen
por: Kanji, Comfort Ropafadzo, et al.
Publicado: (2023) -
Renalase, a catecholamine-metabolising enzyme?
por: Boomsma, F., et al.
Publicado: (2007) -
Purine-Metabolising Enzymes and Apoptosis in Cancer
por: Camici, Marcella, et al.
Publicado: (2019)