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Recapitulation of Tumor Heterogeneity and Molecular Signatures in a 3D Brain Cancer Model with Decreased Sensitivity to Histone Deacetylase Inhibition

INTRODUCTION: Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated using the 3D Rotary Cell Culture System (RCCS). MET...

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Detalles Bibliográficos
Autores principales:	Smith, Stuart J., Wilson, Martin, Ward, Jennifer H., Rahman, Cheryl V., Peet, Andrew C., Macarthur, Donald C., Rose, Felicity R. A. J., Grundy, Richard G., Rahman, Ruman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525561/ https://www.ncbi.nlm.nih.gov/pubmed/23272238 http://dx.doi.org/10.1371/journal.pone.0052335

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